Integrin Alpha2b antibody (FITC)

Catalog No. ABIN127332

Product Details anti-Integrin Alpha2b Antibody (FITC)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Characteristics: Molar Ratio: 15-25 moles of FITC per mole Ig.

Purification: Ion Exchange or Affinity Chromatography.

Immunogen: Washed Human platelets. Remarks: Myeloma cells with spleen cells from Balb/c mice.

Clone: SZ-22

Isotype: IgG1

Application Details

Application Notes: Studies of platelet functions. Identification of gpIIb. Immunohistochemistry on frozen sections or cell smears: 1: 50-1: 100 dilution. Fluorescence Microscopy or Flow Cytometry (20 l/10^6 platelets/test).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 2 mg/mL BSA as stabilizer and 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 / ITGA2B (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Background: The CD41 antigen (platelet GPIIb, alpha IIb integrin) is a Glycoprotein composed of 2 chains, GPIIb alpha (120 kDa) and GPIIb beta (23 kDa), linked by one disulfide bond. (1) CD41 is always non-covalently associated with CD61 (platelet GPIIIa, beta 3 integrin), to form the GPIIb-IIIa (CD41/CD61) complex. The structure and role of the complex CD41/CD61 in hemostasis is reviewed in Ref.2. CD41 is expressed by platelets, Megakaryocytes and by a small subset of CD34+ cells suggesting that CD41/CD61 is the earliest marker of the Megakaryocytic lineage. (3) It has been assigned to the CD41 cluster of differentiation at the 5th International Workshop on Human Leucocyte Differentiation Antigens in Boston, in 1993.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gene ID: 9606

UniProt: P08514

Pathways: Integrin Complex