Amyloid beta Protein (Human) antibody

Overview


	Antigen:	Amyloid beta Protein
	Antibody Type:	Monoclonal
	Application:	Western Blotting (WB), Immunohistochemistry (IHC)
	Reactivity:	Human, Mouse (Murine)
	Host:	Mouse
	Quantity:	100 µg (1 mg/mL)
	Price:	251,00 € (Plus shipping costs and VAT)
	Order number:	ABIN131869
	Availability:	7 to 10 days until shipment

Hints on ordering

Add to basket

Customer Service

Technical Inquiry
Send product details to colleague
Download Datasheet

Additional Information: Amyloid beta Protein (Human) antibody

Antigen	Amyloid beta Protein
Immunogen	This antibody was purified from mouse ascites fluid using protein-A Sepharose. This hybridoma was established by fusion of mouse myeloma cell sp2/0-Ag14 with Balb/c splenocyte immunized with synthetic amyloid ß peptide corresponding to amino acids 1-16 of human amyloid ß.
Reactivity	Human, Mouse (Murine)
Antibody Type	Monoclonal
Format	Lyophilised
Isotype	IgG2b »Matching secondary antibodies
Description	Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases:ß-secretase and .-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.
Clone	2C8
Host	Mouse

Application Details: Amyloid beta Protein (Human) antibody

Application	Western Blotting (WB), Immunohistochemistry (IHC)
Application Notes	Western blotting: 0.5 ~ 1 µg/ml. Immunohistochemistry: 10 µg/ml
Concentration	1 mg/mL
Buffer	100 µg IgG in 100 µL volume of PBS containing 50% glycerol, pH 7.2. Contains no preservatives.
Research Area	Neurology, Alzheimer's Disease
Restrictions	For Research Use Only

Publications: Amyloid beta Protein (Human) antibody

Publications

Vassar, Bennett, Babu-Khan et al.:
"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE."
In: Science (New York, N.Y.) , Vol. 286, Issue 5440, pp. 735-41, 1999/01 (PubMed)

Saito, Pietromonaco, Loo et al.:
"Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family."
In: Proceedings of the National Academy of Sciences of the United States of America , Vol. 91, Issue 21, pp. 9725-9, 1994/01 (PubMed)

Images: Amyloid beta Protein (Human) antibody

Paraffin section of Alzheimer’s disease brain

Image for Amyloid beta Protein (Human) antibody (1)

External Information: Amyloid beta Protein (Human) antibody

Google Scholar	Find more references for clone 2C8 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen Amyloid beta Protein (Bioinformatic Harvester (EMBL))