RT1-BB antibody

Catalog No. ABIN133234

Product Details anti-RT1-BB Antibody

Target: RT1-BB (RT1 Class II, Locus Bb (RT1-BB))

Reactivity: Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This RT1-BB antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Rat RT1.B ( Rat Ia-non-polymorphic)

Purification: Purified

Immunogen: Rat thymocyte membrane glycoprotein. . FUSION PARTNER: P3-NS1-1-Ag4 (NS1/1) . IMMUNOCYTE DONOR: BALB/c spleen

Clone: OX-6

Isotype: IgG1

Application Details

Application Notes: This clone is reported to work with frozen and paraffin sections (5).

Restrictions: For Research Use only

Handling

Concentration: 0,388888889

Storage: 4 °C/-20 °C

Target Details for RT1-BB

Target: RT1-BB (RT1 Class II, Locus Bb (RT1-BB))

Alternative Name: RT1.B (RT1-BB Products)

Synonyms: RT1.B antibody, RT1 class II, locus Bb antibody, RT1-Bb antibody

Background: Anti-rat RT1.B monoclonal antibody recognizes Ia from all rat strains tested. It labels a monomorphic determinant of the rat Ia antigen present on the majority of peripheral B lymphocytes, dendritic cells, some macrophages, and certain epithelial cells (2,3,4) but not peripheral T lymphocytes. (4) This antibody also cross reacts with murine Ia antigens (particularly with k and s haplotypes). Analysis of recombinant strains shows that the determinant maps to the I-A region of the mouse MHC (1,2) and correlates with mouse Ia specificity 17 or 18. Thus, the determinant recognized by ABIN133234is polymorphic in the mouse. This antibody may be useful for recognizing the rat Ia antigen and can be coupled to Sepharose 4B for purification of rat Ia antigen by antibody affinity chromatography (1). This clone is reported to work with frozen and paraffin sections (5).

Pathways: Production of Molecular Mediator of Immune Response