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BCL2L1 antibody (BCL2-Like 1) (N-Term)

Details for Product anti-BCL2L1 Antibody No. ABIN135025, Supplier: Log in to see
Antigen
  • bcl-XL
  • bcl-x
  • bcl-x(l)
  • bcl-xl/s
  • bcl-xs
  • bcl2l
  • bclx
  • bclxl
  • xR11
  • BCL2L1
  • Bcl-xS
  • BCL-XL/S
  • BCL2L
  • BCLX
  • BCLXL
  • BCLXS
  • Bcl-X
  • PPP1R52
  • bcl-xL
  • bcl-xS
  • Bcl(X)L
  • Bcl-XL
  • Bcl-Xs
  • Bcl2l
  • BclX
  • Bcl-xl
  • Bclx
  • bcl-X
  • BCL-XL
  • Bcl-xL
  • bcl-xl
  • BCL2-like 1
  • transgene insertion 2, Craig B Thompson
  • Bcl2-like 1
  • bcl2l1
  • BCL2L1
  • LOC100224900
  • Tg(BCL2L1)2Cbt
  • Bcl2l1
Alternatives
anti-Human BCL2L1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term, AA 3-14
148
36
27
22
19
13
13
13
11
11
10
7
7
7
6
5
5
5
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
476
300
275
134
18
8
7
6
4
4
2
2
1
1
1
Host
Mouse
279
228
4
3
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL2L1 antibody is un-conjugated
24
15
10
9
7
7
6
5
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
386
191
165
160
155
151
119
98
96
23
10
7
4
3
3
2
1
1
Options
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Immunogen KLH-conjugated peptide corresponding to AA 3-14 near the N-terminus mouse and human Bcl-xL1 Ig
Clone 2H12
Isotype IgG2a
Characteristics The antibody detects: Mouse and human Bcl-xL (Mr 29 kDa)
Purification Purified
Alternative Name Bcl-xL (BCL2L1 Antibody Abstract)
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
Research Area Cancer
Pathways Apoptosis
Application Notes Working Dilution:
Immunohistochemistry: 5-10 µg/mL
Western Blotting: 1 µg/mL
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Without preservative
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Background publications Hsu, Wolter, Youle: "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3668-72, 1997 (PubMed).

Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers, Wu, Umansky, Tomei, Barr: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Boise, González-García, Postema, Ding, Lindsten, Turka, Mao, Nuñez, Thompson: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).