CD11b antibody (Integrin alpha M)

Details for Product anti-ITGAM Antibody No. ABIN135128, Supplier: Log in to see
Antigen
  • CD11b/CD18
  • CR3
  • CR3A
  • Cd11b
  • F730045J24Rik
  • Ly-40
  • MAC1
  • Mac-1
  • Mac-1a
  • CD11B
  • MAC-1
  • MAC1A
  • MO1A
  • SLEB6
  • C3bi
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • integrin alpha M
  • integrin, alpha M
  • ITGAM
  • Itgam
Alternatives
anti-Mouse (Murine) CD11b antibody for Biochemical Assay
Reactivity
Mouse (Murine)
709
493
192
78
31
19
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4
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2
Host
Rat
510
389
166
16
6
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD11b antibody is un-conjugated
152
124
92
52
20
19
15
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2
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2
1
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1
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
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235
228
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170
142
98
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25
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13
8
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3
1
1
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1
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Options
Supplier
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Immunogen Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice1
Clone 3A33
Isotype IgG2a
Characteristics The antibody detects: M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer
Purification Purified
Alternative Name CD11b/Mac-1a (ITGAM Antibody Abstract)
Background CD11b (integrin M subunit) combines with CD18 (integrin 2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
Pathways Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Background publications Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, 1994 (PubMed).