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CTLA4 antibody (Cytotoxic T-Lymphocyte-Associated Protein 4) (Biotin)

Details for Product anti-CTLA4 Antibody No. ABIN135315, Supplier: Log in to see
Antigen
  • CTLA-4
  • CTLA4
  • CD152
  • Cd152
  • Ctla-4
  • Ly-56
  • CD
  • CELIAC3
  • GRD4
  • GSE
  • IDDM12
  • sCTLA4
Reactivity
Mouse (Murine)
181
132
51
7
2
2
Host
Hamster
158
90
78
12
5
4
Clonality (Clone)
Monoclonal ()
Conjugate
This CTLA4 antibody is conjugated to Biotin
53
32
32
15
7
4
3
2
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
219
100
98
56
46
28
20
20
17
7
6
6
5
5
4
4
4
3
2
2
2
1
1
1
1
Supplier
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Clone 1B8
Isotype IgG
Characteristics The antibody detects: Mouse CD152/CTLA-4
Alternative Name CD152/CTLA-4 (CTLA4 Antibody Abstract)
Background The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. However CD152 is thought to be a negative regulator of T cell activation and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer, and is relatively conserved among humans, mice and chickens.
Pathways
Application Notes Working Dilution:
FACS: 3 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

In vitro functional studies

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg in 1.0 mL of PBS / NaN3.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Background publications Perkins, Wang, Donovan et al.: "Regulation of CTLA-4 expression during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4154-9, 1996 (PubMed).

Leach, Krummel, Allison: "Enhancement of antitumor immunity by CTLA-4 blockade." in: Science (New York, N.Y.), Vol. 271, Issue 5256, pp. 1734-6, 1996 (PubMed).

Walunas, Lenschow, Bakker et al.: "CTLA-4 can function as a negative regulator of T cell activation." in: Immunity, Vol. 1, Issue 5, pp. 405-13, 1995 (PubMed).

Freeman, Lombard, Gimmi et al.: "CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 12, pp. 3795-801, 1993 (PubMed).