Progesterone Receptor (PGR) (AA 1-101) antibody

Details for Product No. ABIN136265
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Antigen
Synonyms PR, XPR-1, pgr, xpr-2, PGR, pg, pr, gb:dq017620, NR3C3, 9930019P03Rik, BB114106, ENSMUSG00000074510, PR-A, PR-B, LOC443444
Epitope
AA 1-101
(49), (39), (25), (21), (15), (14), (11), (9), (9), (8), (8), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(386), (73), (71), (14), (12), (7), (6), (3), (2), (2), (1), (1), (1)
Host
Mouse
(252), (159), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(269), (147), (98), (96), (61), (53), (52), (39), (30), (6), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN136265
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Immunogen 6-His fusion protein containing the region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.
Clone 4D8
Isotype IgG2a
Fragment Light chain,Chain kappa
Specificity This antibody recognizes both Form A (94 kDa) and Form B (120kDa) of the human progesterone receptor (PgR)
Characteristics Cellular Localization: Nuclear
Purification Protein G affinity purified. From hybridoma tissue culture supernatant.
Alternative Name Progesterone receptor
Background The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.
Synonyms: progesterone receptor PgR Anti-NR3C3 Anti-PGR Anti-PR Anti-Progesterone Receptor NR3C3 antibody PGR antibody PR antibody
Research Area Hormones, Receptors
Application Notes WB: Use at a concentration of 1-5 ug/ml. Predicted molecular weight: 99 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Comment

Positive Controls: MCF7 lysate (GTX23871) & recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH 7.2, containing no preservatives
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
General Bagchi, Elliston, Tsai et al.: "Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element." in: Molecular endocrinology (Baltimore, Md.), Vol. 2, Issue 12, pp. 1221-9, 1989 (PubMed).

Evans: "The steroid and thyroid hormone receptor superfamily." in: Science (New York, N.Y.), Vol. 240, Issue 4854, pp. 889-95, 1988 (PubMed).

Beato, Herrlich, Schütz: "Steroid hormone receptors: many actors in search of a plot." in: Cell, Vol. 83, Issue 6, pp. 851-7, 1996 (PubMed).

Edwards: "Coregulatory proteins in nuclear hormone receptor action." in: Vitamins and hormones, Vol. 55, pp. 165-218, 1999 (PubMed).

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