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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Progesterone Receptor (PGR) antibody
|Synonyms||PR, NR3C3, PR-A, PR-B, BB114106, 9930019P03Rik, ENSMUSG00000074510, PGR, pgr-A, XPR-1, LOC443444, pg, pr, gb:dq017620|
Alternatives Western Blotting (WB)
|4 references available|
|Quantity||0.1 mg (1 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Alternative name||Progesterone receptor|
|Immunogen||6-His fusion protein containing the region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.|
|Description||The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.|
|Specificity||This antibody recognizes both Form A (94 kDa) and Form B (120kDa) of the human progesterone receptor (PgR)|
|Application Notes||WB: Use at a concentration of 1-5 ug/ml. Predicted molecular weight: 99 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.|
|Purification||Protein G affinity purified|
|Buffer||Phosphate-buffered saline, pH 7.2, containing no preservatives|
|Research Area||Hormones, Receptors|
|Restrictions||For Research Use only|
Bagchi, Elliston, Tsai et al.: "Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element." in: Molecular endocrinology (Baltimore, Md.), Vol. 2, Issue 12, pp. 1221-9, 1989 (PubMed).
Evans: "The steroid and thyroid hormone receptor superfamily." in: Science (New York, N.Y.), Vol. 240, Issue 4854, pp. 889-95, 1988 (PubMed).
Beato, Herrlich, Schütz: "Steroid hormone receptors: many actors in search of a plot." in: Cell, Vol. 83, Issue 6, pp. 851-7, 1996 (PubMed).
Edwards: "Coregulatory proteins in nuclear hormone receptor action." in: Vitamins and hormones, Vol. 55, pp. 165-218, 1999 (PubMed).