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Progesterone Receptor (PGR) antibody

Details for Product No. ABIN136265
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Antigen
Synonyms PR, NR3C3, PR-A, PR-B, BB114106, 9930019P03Rik, ENSMUSG00000074510, XPR-1, pgr, xpr-2, LOC443444, PGR, pg, pr, gb:dq017620
Reactivity
Human
(385), (72), (72), (14), (12), (7), (6), (3), (2), (2), (1), (1), (1)
Host
Mouse
(249), (160), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(8), (8), (8), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(265), (149), (102), (96), (58), (52), (52), (35), (30), (6), (3), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Catalog No. ABIN136265
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen 6-His fusion protein containing the region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.
Isotype IgG2a
Specificity This antibody recognizes both Form A (94 kDa) and Form B (120kDa) of the human progesterone receptor (PgR)
Purification Protein G affinity purified
Alternative Name Progesterone receptor
Background The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.
Research Area Hormones, Receptors
Application Notes WB: Use at a concentration of 1-5 ug/ml. Predicted molecular weight: 99 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, containing no preservatives
General Bagchi, Elliston, Tsai et al.: "Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element." in: Molecular endocrinology (Baltimore, Md.), Vol. 2, Issue 12, pp. 1221-9, 1989 (PubMed).

Evans: "The steroid and thyroid hormone receptor superfamily." in: Science (New York, N.Y.), Vol. 240, Issue 4854, pp. 889-95, 1988 (PubMed).

Beato, Herrlich, Schütz: "Steroid hormone receptors: many actors in search of a plot." in: Cell, Vol. 83, Issue 6, pp. 851-7, 1996 (PubMed).

Edwards: "Coregulatory proteins in nuclear hormone receptor action." in: Vitamins and hormones, Vol. 55, pp. 165-218, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN136265
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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