Breast Cancer 2, Early Onset (BRCA2) (AA 188-563) antibody

Details for Product No. ABIN136310
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Antigen
Synonyms fancd1, brca2, BRCA2, brcc2, brovca2, facd, fad, fad1, fancb, AI256696, AW045498, Fancd1, RAB163, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Epitope
AA 188-563
(16), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(57), (28), (23), (13), (13), (12), (1), (1), (1)
Host
Mouse
(52), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(32), (23), (16), (10), (5), (3), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN136310
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Immunogen Amino acids 188-563 of human BRCA2 expressed in E. coli. BRCA2-BBA.
Clone 3E6
Isotype IgG1
Fragment Light chain,Chain kappa
Specificity This antibody recognizes the BRCA2 gene product, a 390-kDa nuclear protein.
Characteristics Cellular Localization: Nuclear
Purification Protein G affinity purified. From mouse ascitic fluid.
Alternative Name BRCA2 / FANCD1
Background The BRCA2 antibody clone 3E6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Synonyms: 114480, FACD, FANCB, P51587, FANCD1, BRCC2, BRCA2, FANCD, 675, FAD1, FAD
Molecular Weight 390 kDa
Application Notes Do not boil samples for longer than two minutes. For IP: Use at a concentration of 2-5 ug/ml. For WB: Use at a concentration of 1-5 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -80 °C
Storage Comment For long term storage, please keep at -70 °C or below.
General Sonnhof, Grafe, Krumnikl et al.: "Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord." in: Brain research, Vol. 100, Issue 2, pp. 327-41, 1976 (PubMed).

Chen, Chen, Chen et al.: "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5287-92, 1998 (PubMed).

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