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Details for Product No. ABIN136310

Breast Cancer 2, Early Onset (BRCA2) antibody

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Antigen
Synonyms BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, fancd1, brca2, BRCA2, brcc2, brovca2, facd, fad, fad1, fancb
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN136310
Quantity 0.1 mg
Price
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Immunogen Amino acids 188-563 of human BRCA2 expressed in E. coli. BRCA2-BBA.
Isotype IgG1
Purification Protein G affinity purified
Alternative Name BRCA2 / FANCD1
Background BRCA2-3E6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Application Notes Do not boil samples for longer than two minutes. For IP: Use at a concentration of 2-5 ug/ml. For WB: Use at a concentration of 1-5 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Sonnhof, Grafe, Krumnikl et al.: "Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord." in: Brain research, Vol. 100, Issue 2, pp. 327-41, 1976 (PubMed).

Chen, Chen, Chen et al.: "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5287-92, 1998 (PubMed).

Alternatives for antigen "Breast Cancer 2, Early Onset (BRCA2)", type "Antibodies"
Hosts (35), (8)
Reactivities (43), (18), (18), (13), (12), (12), (1), (1), (1)
Applications (25), (15), (10), (9), (4), (3), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (2), (1), (1), (1)
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