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Breast Cancer 2, Early Onset (BRCA2) antibody

Details for Product No. ABIN136310
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Antigen
Synonyms BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, fancd1, brca2, BRCA2, brcc2, brovca2, facd, fad, fad1, fancb
Reactivity
Human
(46), (23), (22), (13), (13), (12), (1), (1), (1)
Host
Mouse
(41), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(27), (19), (11), (10), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Catalog No. ABIN136310
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  • +1 404 474 4654
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Immunogen Amino acids 188-563 of human BRCA2 expressed in E. coli. BRCA2-BBA.
Isotype IgG1
Purification Protein G affinity purified
Alternative Name BRCA2 / FANCD1
Background BRCA2-3E6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Application Notes Do not boil samples for longer than two minutes. For IP: Use at a concentration of 2-5 ug/ml. For WB: Use at a concentration of 1-5 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
General Sonnhof, Grafe, Krumnikl et al.: "Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord." in: Brain research, Vol. 100, Issue 2, pp. 327-41, 1976 (PubMed).

Chen, Chen, Chen et al.: "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5287-92, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN136310
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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