Breast Cancer 2, Early Onset (BRCA2) (AA 2336-2478) antibody

Details for Product No. ABIN136315
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Antigen
Synonyms fancd1, brca2, BRCA2, brcc2, brovca2, facd, fad, fad1, fancb, AI256696, AW045498, Fancd1, RAB163, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Epitope
AA 2336-2478
(11), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(48), (25), (23), (13), (13), (12), (1), (1), (1)
Host
Mouse
(43), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(28), (18), (13), (10), (4), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN136315
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Immunogen BRCA2 protein fragment containing amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.
Clone 9D3
Isotype IgG1
Fragment Light chain,Chain kappa
Specificity This antibody recognizes BRCA2, a 390-kDa nuclear protein.
Characteristics Cellular Localization: Nuclear
Purification Protein G affinity purified.. From mouse ascitic fluid..
Alternative Name BRCA2 / FANCD1
Background BRCA2-9D3 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Synonyms: 114480, FACD, FANCB, P51587, FANCD1, BRCC2, BRCA2, FANCD, 675, FAD1, FAD
Molecular Weight 390 kDa
Application Notes Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Comment

Positive Controls: HCT116

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
General Chen, Chen, Chen et al.: "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5287-92, 1998 (PubMed).

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