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ATM antibody (Ataxia Telangiectasia Mutated)

Details for Product anti-ATM Antibody No. ABIN136323, Supplier: Login to see
Antigen
Alternatives
anti-Human ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
297
74
30
6
4
1
1
Host
Mouse
213
58
16
8
4
Clonality
Monoclonal
Conjugate
This ATM antibody is un-conjugated
8
8
6
6
6
6
4
2
2
2
2
2
2
2
2
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
171
79
71
52
42
41
25
22
16
11
5
4
4
2
2
1
1
1
1
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Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Isotype IgG1
Cross-Reactivity Monkey, Mouse (Murine), Rat (Rattus)
Purification Protein G affinity purified
Alternative Name ATM (ATM Antibody Abstract)
Background ATM-2C1 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair
Application Notes For WB: Use at a dilution of 1:500-1:1,000. For IP: Use at a concentration of 1-10 ug/ml. Immunohistochemistry analyses was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice-(MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH7.4, containing no preservatives
Supplier Images
Immunohistochemistry (IHC) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody
Immunohistochemistry (IHC) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody (Image 2)
Immunoprecipitation (IP) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody (Image 3)
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody (Image 4)
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody (Image 5)
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136323) anti-Ataxia Telangiectasia Mutated (ATM) antibody (Image 6)
Background publications Scherthan, Jerratsch, Dhar et al.: "Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7773-83, 2000 (PubMed).

Chen, Lee EYHP: "The product of the ATM gene is a 370-kDa nuclear phosphoprotein." in: The Journal of biological chemistry, Vol. 271, Issue 52, pp. 33693-7, 1997 (PubMed).