Ataxia Telangiectasia Mutated (ATM) antibody

Details for Product No. ABIN136323
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Antigen
Synonyms ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik
Reactivity
Human
(226), (65), (38), (3), (2), (1), (1)
Host
Mouse
(163), (40), (16), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (1), (1), (1)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(124), (50), (49), (47), (43), (40), (33), (12), (12), (5), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN136323
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Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Isotype IgG1
Cross-Reactivity Monkey, Mouse (Murine), Rat (Rattus)
Purification Protein G affinity purified
Alternative Name ATM
Background ATM-2C1 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Research Area Cancer, DNA/RNA
Application Notes For WB: Use at a dilution of 1:500-1:1,000. For IP: Use at a concentration of 1-10 ug/ml. Immunohistochemistry analyses was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice-(MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH7.4, containing no preservatives
General Chen, Lee EYHP: "The product of the ATM gene is a 370-kDa nuclear phosphoprotein." in: The Journal of biological chemistry, Vol. 271, Issue 52, pp. 33693-7, 1997 (PubMed).

Scherthan, Jerratsch, Dhar et al.: "Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7773-83, 2000 (PubMed).

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