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ATM antibody (Ataxia Telangiectasia Mutated)

Details for Product anti-ATM Antibody No. ABIN136325, Supplier: Login to see
Antigen
Alternatives
anti-Human ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
297
74
30
6
4
1
1
Host
Mouse
213
58
16
8
4
Clonality
Monoclonal
Conjugate
This ATM antibody is un-conjugated
8
8
6
6
6
6
4
2
2
2
2
2
2
2
2
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
171
79
71
52
42
41
25
22
16
11
5
4
4
2
2
1
1
1
1
Supplier
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Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Isotype IgG1
Cross-Reactivity Monkey, Mouse (Murine), Rat (Rattus)
Purification Protein G affinity purified
Alternative Name ATM (ATM Antibody Abstract)
Background ATM-3E8 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair
Application Notes For IP: Use at a concentration of 2-10 ug/ml. For WB: Use at a concentration of 1-2 ug/ml. Predicted moolecular weight: 350kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH7.4, containing no preservatives
Supplier Images
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN136325) anti-Ataxia Telangiectasia Mutated (ATM) antibody
Background publications Chen, Lin, Lieberman et al.: "ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16580-6, 2001 (PubMed).

Stein: "The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1659-62, 1976 (PubMed).