Ataxia Telangiectasia Mutated (ATM) antibody

Details for Product No. ABIN136325
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Antigen
Synonyms ATM, Atm, CG6535, Dmel\\CG6535, Tefu, atm, atm/tefu, dATM, tef, Xatm, at1, atdc, tel1, telo1, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, AI256621, C030026E19Rik
Reactivity
Human
(231), (65), (38), (3), (2), (1), (1)
Host
Mouse
(168), (40), (16), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(128), (52), (49), (49), (46), (40), (37), (15), (12), (5), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN136325
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Immunogen Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Isotype IgG1
Cross-Reactivity Monkey, Mouse (Murine), Rat (Rattus)
Purification Protein G affinity purified
Alternative Name ATM
Background ATM-3E8 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Research Area Cancer, DNA/RNA
Application Notes For IP: Use at a concentration of 2-10 ug/ml. For WB: Use at a concentration of 1-2 ug/ml. Predicted moolecular weight: 350kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH7.4, containing no preservatives
General Stein: "The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1659-62, 1976 (PubMed).

Chen, Lin, Lieberman et al.: "ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16580-6, 2001 (PubMed).

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