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ATR antibody (Ataxia Telangiectasia and Rad3 Related) (AA 710-1100)

Details for Product anti-ATR Antibody No. ABIN136334, Supplier: Login to see
Antigen
Alternatives
anti-Human ATR antibody for Western Blotting
Epitope
AA 710-1100
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
16
5
2
1
1
1
1
1
1
Host
Mouse
13
3
Clonality (Clone)
Monoclonal ()
Application
Functional Studies (Func), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
13
2
2
2
2
1
1
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Immunogen Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.
Clone 2B5
Isotype IgG
Purification Protein G purified. From Ascites.
Alternative Name ATR / FRP1 (ATR Antibody Abstract)
Background Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.
Synonyms: SCKL1, Q13535, ATR, 210600, MEC1, FRP1, SCKL, 545
Molecular Weight 317 kDa
Pathways p53 Signaling, Apoptosis, DNA Damage Repair
Application Notes For WB: Use at a dilution of 1:500-1,000. For IP and IF information please refer to publications. Not yet tested in other applications. Optimal dilution should be determind by the researcher.
Comment

Positive Controls: Raji whole cell lysate

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH7.2
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
 image for anti-ATR antibody (Ataxia Telangiectasia and Rad3 Related) (AA 710-1100) (ABIN136334) anti-Ataxia Telangiectasia and Rad3 Related (ATR) (AA 710-1100) antibody
Background publications Wu, Shell, Liu et al.: "ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation." in: Oncogene, Vol. 26, Issue 5, pp. 757-64, 2007 (PubMed).

Bradbury, Jackson: "ATM and ATR." in: Current biology : CB, Vol. 13, Issue 12, pp. R468, 2003 (PubMed).

Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).