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Details for Product No. ABIN136334

Ataxia Telangiectasia and Rad3 Related (ATR) antibody

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FCTCS, FRP1, MEC1, SCKL, SCKL1, XATR, frp1, mec1, sckl, sckl1, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, ATRAD3, Ataxia telangiectasia-mutated and RAD3-related, MHK7. ... show more
»Alternatives Human
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN136334
Quantity 0.1 mg
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Immunogen Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.
Isotype IgG
Purification Protein G affinity purified
Alternative Name ATR / FRP1
Background Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.
Application Notes For WB: Use at a dilution of 1:500-1,000. For IP and IF information please refer to publications. Not yet tested in other applications. Optimal dilution should be determind by the researcher.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH7.2
Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).

Bradbury, Jackson: "ATM and ATR." in: Current biology : CB, Vol. 13, Issue 12, pp. R468, 2003 (PubMed).

Wu, Shell, Liu et al.: "ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation." in: Oncogene, Vol. 26, Issue 5, pp. 757-64, 2007 (PubMed).

Alternatives for antigen "Ataxia Telangiectasia and Rad3 Related (ATR)", type "Antibodies"
Hosts (22), (6), (1)
Reactivities (26), (9), (4), (2), (2), (1), (1), (1), (1)
Applications (20), (8), (7), (5), (2), (1)
Epitopes (3), (2), (1), (1), (1), (1), (1), (1)