Ataxia Telangiectasia and Rad3 Related (ATR) antibody

Antigen: Ataxia Telangiectasia and Rad3 Related (ATR)

Synonyms: FRP1, MEC1, SCKL, SCKL1, ATR, atr, XATR, frp1, mec1, sckl, sckl1

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)

Catalog no.: ABIN136334

Additional Information

Alternative name: ATR / FRP1

Immunogen: Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.

Cross-Reactivity: Human

Isotype: IgG

Description: Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.

Application Details

Application Notes: For WB: Use at a dilution of 1:500-1,000. For IP and IF information please refer to publications. Not yet tested in other applications. Optimal dilution should be determind by the researcher.

Concentration: 1 mg/ml

Purification: Protein G affinity purified

Buffer: Phosphate-buffered saline, pH7.2

Restrictions: For Research Use only

Images

anti-Ataxia Telangiectasia and Rad3 Related (ATR) antibody

Publications

Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).

Bradbury, Jackson: "ATM and ATR." in: Current biology : CB, Vol. 13, Issue 12, pp. R468, 2003 (PubMed).

Wu, Shell, Liu et al.: "ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation." in: Oncogene, Vol. 26, Issue 5, pp. 757-64, 2007 (PubMed).