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Details for Product No. ABIN136436

Fanconi Anemia, Complementation Group D2 (FANCD2) antibody

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Synonyms FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, FAD2, FANCD2, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, xfancd2
»Alternatives Human
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), ELISA
Pubmed 4 references available
Catalog no. ABIN136436
Quantity 0.1 mg
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Immunogen Human FANCD2 fusion protein
Isotype IgG
Purification Protein G affinity purified
Alternative Name FANCD2
Background Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Recommended dilution for western blotting: 1:1000. Recommended secondary: anti-mouse IgG
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Storage -80 °C
Strathdee, Duncan, Buchwald: "Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9." in: Nature genetics, Vol. 1, Issue 3, pp. 196-8, 1993 (PubMed).

Timmers, Taniguchi, Hejna et al.: "Positional cloning of a novel Fanconi anemia gene, FANCD2." in: Molecular cell, Vol. 7, Issue 2, pp. 241-8, 2001 (PubMed).

Garcia-Higuera, Taniguchi, Ganesan et al.: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

Nakanishi, Taniguchi, Ranganathan et al.: "Interaction of FANCD2 and NBS1 in the DNA damage response." in: Nature cell biology, Vol. 4, Issue 12, pp. 913-20, 2002 (PubMed).

Alternatives for antigen "Fanconi Anemia, Complementation Group D2 (FANCD2)", type "Antibodies"
Hosts (86), (16)
Reactivities (96), (51), (41), (36), (24), (24), (3), (3), (2)
Applications (67), (31), (30), (30), (23), (21), (16), (5), (2), (2), (1)
Conjugates (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (22), (12), (8), (2), (2), (1), (1)