Fanconi Anemia, Complementation Group D2 (FANCD2) antibody

Details for Product No. ABIN136436
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Antigen
Synonyms FANCD2, CG17269, CG31192, CG31194, Dmel\\CG17269, dmFANCD2, xfancd2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, 2410150O07Rik, AU015151, BB137857
Reactivity
Human
(91), (55), (46), (36), (24), (24), (6)
Host
Mouse
(87), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(61), (33), (30), (24), (23), (16), (12), (10), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN136436
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Immunogen Human FANCD2 fusion protein
Clone 103
Isotype IgG
Characteristics Cellular Localization: Nuclear
Purification Protein G affinity purified.. From mouse ascitic fluid..
Alternative Name FANCD2
Background Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1
Synonyms: FACD, FA-D2, 2177, FANCD2, FA4, FANCD, DKFZp762A223, 227646, Q9BXW9, FAD, FAD2, FA D2
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Recommended dilution for western blotting: 1:1000. Recommended secondary: anti-mouse IgG
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH 7.2, containing no preservatives
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
anti-Fanconi Anemia, Complementation Group D2 (FANCD2) antibody anti-Fanconi Anemia, Complementation Group D2 (FANCD2) antibody
General Strathdee, Duncan, Buchwald: "Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9." in: Nature genetics, Vol. 1, Issue 3, pp. 196-8, 1993 (PubMed).

Timmers, Taniguchi, Hejna et al.: "Positional cloning of a novel Fanconi anemia gene, FANCD2." in: Molecular cell, Vol. 7, Issue 2, pp. 241-8, 2001 (PubMed).

Garcia-Higuera, Taniguchi, Ganesan et al.: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

Nakanishi, Taniguchi, Ranganathan et al.: "Interaction of FANCD2 and NBS1 in the DNA damage response." in: Nature cell biology, Vol. 4, Issue 12, pp. 913-20, 2002 (PubMed).

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