Fanconi Anemia, Complementation Group D2 (FANCD2) antibody

Antigen: Fanconi Anemia, Complementation Group D2 (FANCD2)

Synonyms: FANCD2, CG31192, CG31194, dmFANCD2, Dmel\CG17269, CG17269, FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, fancd2

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Catalog no.: ABIN136436

Additional Information

Alternative name: FANCD2

Immunogen: Human FANCD2 fusion protein

Cross-Reactivity: Human

Isotype: IgG

Description: Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1

Application Details

Application Notes: Recommended dilution for western blotting: 1:1000. Recommended secondary: anti-mouse IgG

Concentration: 1 mg/ml

Purification: Protein G affinity purified

Buffer: Phosphate-buffered saline, pH 7.2, no preservative added.

Storage: For long term storage, please keep at -70 C or below. Avoid repeared freeze-thaw cycles.

Research Area: Chromatin and Nuclear Signaling, DNA/RNA

Restrictions: For Research Use only

Images

anti-Fanconi Anemia, Complementation Group D2 (FANCD2) antibody

Publications

Strathdee, Duncan, Buchwald: "Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9." in: Nature genetics, Vol. 1, Issue 3, pp. 196-8, 1993 (PubMed).

Timmers, Taniguchi, Hejna et al.: "Positional cloning of a novel Fanconi anemia gene, FANCD2." in: Molecular cell, Vol. 7, Issue 2, pp. 241-8, 2001 (PubMed).

Garcia-Higuera, Taniguchi, Ganesan et al.: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

Nakanishi, Taniguchi, Ranganathan et al.: "Interaction of FANCD2 and NBS1 in the DNA damage response." in: Nature cell biology, Vol. 4, Issue 12, pp. 913-20, 2002 (PubMed).