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Details for Product No. ABIN137205

Checkpoint Kinase 2 (CHEK2) antibody

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Antigen
Synonyms CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, Cds1, Rad53, HUCDS1, Chk2, CHK-2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN137205
Quantity 0.1 mg
Price
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Immunogen Recombinant CHK2 protein
Isotype IgG
Specificity ABIN137205 is specific for human CHK2 protein.
Purification Protein G affinity purified
Purity >95% by SDS-PAGE
Alternative Name CHK2
Background CHK2 controls cell cycle checkpoint and may participate in transduction of the DNA damage and replicational stress signals. CHK2 belongs to the Ser/Thr protein kinase family and its kinase actibity is up-regulated by autophosphorylation, It is phosphorylated rapidly in response to DNA damage and to replication block.
Application Notes For western blot, use 1:1000 dilution to detect CHK2 protein in ~20-40 ug total cell extract.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Preservative Without preservative
Storage -80 °C
Brody: "CHEKs and balances: accounting for breast cancer." in: Nature genetics, Vol. 31, Issue 1, pp. 3-4, 2002 (PubMed).

Ahn, Urist, Prives: "Questioning the role of checkpoint kinase 2 in the p53 DNA damage response." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20480-9, 2003 (PubMed).

Jallepalli, Lengauer, Vogelstein et al.: "The Chk2 tumor suppressor is not required for p53 responses in human cancer cells." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20475-9, 2003 (PubMed).

Stevens, Smith, La Thangue: "Chk2 activates E2F-1 in response to DNA damage." in: Nature cell biology, Vol. 5, Issue 5, pp. 401-9, 2003 (PubMed).

Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).

Tan, Guschin, Davalos et al.: "Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 21, pp. 11997-2002, 2003 (PubMed).

Lipton, Fleischmann, Sieber et al.: "Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma." in: Cancer letters, Vol. 200, Issue 2, pp. 149-52, 2003 (PubMed).

Alternatives for antigen "Checkpoint Kinase 2 (CHEK2)", type "Antibodies"
Hosts (259), (69), (1)
Reactivities (319), (144), (143), (55), (37), (36), (12), (4), (3), (1), (1)
Applications (243), (115), (75), (67), (60), (34), (26), (19), (8), (3), (3), (2)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Epitopes (36), (33), (25), (24), (19), (13), (11), (8), (7), (6), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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