Add to Basket
|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Checkpoint Kinase 2 (CHEK2) antibody
|Synonyms||CDS1, CHK2, LFS2, RAD53, HuCds1, PP1425|
Alternatives Western Blotting (WB)
|7 references available|
|Quantity||0.1 mg (1 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Immunogen||Recombinant CHK2 protein|
|Description||CHK2 controls cell cycle checkpoint and may participate in transduction of the DNA damage and replicational stress signals. CHK2 belongs to the Ser/Thr protein kinase family and its kinase actibity is up-regulated by autophosphorylation, It is phosphorylated rapidly in response to DNA damage and to replication block.|
|Specificity||ABIN137205 is specific for human CHK2 protein.|
|Application Notes||For western blot, use 1:1000 dilution to detect CHK2 protein in ~20-40 ug total cell extract.|
|Purity||>95% by SDS-PAGE|
|Purification||Protein G affinity purified|
|Buffer||Phosphate-buffered saline, pH 7.2, no preservative added.|
|Preservative||containing no preservatives|
|Storage||For long term storage, please keep at -70 C or below. Avoid repeared freeze-thaw cycles.|
|Restrictions||For Research Use only|
|anti-Checkpoint Kinase 2 (CHEK2) antibody|
Brody: "CHEKs and balances: accounting for breast cancer." in: Nature genetics, Vol. 31, Issue 1, pp. 3-4, 2002 (PubMed).
Ahn, Urist, Prives: "Questioning the role of checkpoint kinase 2 in the p53 DNA damage response." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20480-9, 2003 (PubMed).
Jallepalli, Lengauer, Vogelstein et al.: "The Chk2 tumor suppressor is not required for p53 responses in human cancer cells." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20475-9, 2003 (PubMed).
Stevens, Smith, La Thangue: "Chk2 activates E2F-1 in response to DNA damage." in: Nature cell biology, Vol. 5, Issue 5, pp. 401-9, 2003 (PubMed).
Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).
Tan, Guschin, Davalos et al.: "Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 21, pp. 11997-2002, 2003 (PubMed).
Lipton, Fleischmann, Sieber et al.: "Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma." in: Cancer letters, Vol. 200, Issue 2, pp. 149-52, 2003 (PubMed).