Checkpoint Kinase 2 (CHEK2) antibody

Details for Product No. ABIN137205
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Antigen
Synonyms CHK-2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, Cds1, HUCDS1, Rad53, Chk2, fa66f08, wu:fa66f08, zgc:55865
Reactivity
Human
(350), (147), (146), (55), (37), (36), (12), (7), (6), (1)
Host
Mouse
(285), (72), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(275), (110), (96), (67), (60), (46), (35), (31), (16), (4), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN137205
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Immunogen Recombinant CHK2 protein
Clone 8F12
Isotype IgG
Specificity Product is specific for human CHK2 protein.
Characteristics Cellular Localization: Nuclear
Purification Protein G affinity purified
Purity > 95 % by SDS-PAGE
Alternative Name CHK2
Background CHK2 controls cell cycle checkpoint and may participate in transduction of the DNA damage and replicational stress signals. CHK2 belongs to the Ser/Thr protein kinase family and its kinase actibity is up-regulated by autophosphorylation, It is phosphorylated rapidly in response to DNA damage and to replication block.
Synonyms: HuCds1, 114480, CHK2, CDS1 CHK2 HuCds1 PP1425 RAD53 bA444G7 checkpoint kinase 2 checkpoint-like protein CHK2 11200, PP1425, CDS1 CHK2 HuCds1 PP1425 RAD53 bA444G7 checkpoint kinase2 checkpointlike protein CHK211200, CDS1 CHK2 HuCds1 PP1425 RAD53 bA444G7 checkpoint kinase 2 checkpointlike protein CHK2 11200, LFS2, RAD53, O96017, CHEK2, CDS1
Molecular Weight ~61 kD
Application Notes For western blot, use 1:1000 dilution to detect CHK2 protein in ~20-40 ug total cell extract.
Comment

Positive Controls: HepG2, MCF-7, or LN-Cap total cell extract

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, pH 7.2, containing no preservatives
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
anti-Checkpoint Kinase 2 (CHEK2) antibody anti-Checkpoint Kinase 2 (CHEK2) antibody
General Brody: "CHEKs and balances: accounting for breast cancer." in: Nature genetics, Vol. 31, Issue 1, pp. 3-4, 2002 (PubMed).

Ahn, Urist, Prives: "Questioning the role of checkpoint kinase 2 in the p53 DNA damage response." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20480-9, 2003 (PubMed).

Jallepalli, Lengauer, Vogelstein et al.: "The Chk2 tumor suppressor is not required for p53 responses in human cancer cells." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20475-9, 2003 (PubMed).

Stevens, Smith, La Thangue: "Chk2 activates E2F-1 in response to DNA damage." in: Nature cell biology, Vol. 5, Issue 5, pp. 401-9, 2003 (PubMed).

Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).

Tan, Guschin, Davalos et al.: "Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 21, pp. 11997-2002, 2003 (PubMed).

Lipton, Fleischmann, Sieber et al.: "Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma." in: Cancer letters, Vol. 200, Issue 2, pp. 149-52, 2003 (PubMed).

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