X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) antibody

Antigen: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3)

Clonality: Polyclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN137699

Additional Information

Alternative name: XRCC3

Immunogen: Human XRCC3, over-expressed in E. coli

Isotype: IgG1  (Matching secondary antibodies)

Description: Five human RAD51 homologs have been identified: XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D. Each of these homologs interacts with one or more of the others, with all of the proteins involved in one complex or multiple smaller complexes.XRCC3 (x-ray cross complementing) was first identified as a human gene complementing the DNA damage sensitivity, chromosonal instability and impaired growth of the mutant hamster cell line irs1SF. This fact coupled with XRCC3 being a member of the RAD51 gene family have implied a role in the repair of DNA damage by homologous recombination.

Specificity: This antibody is specific for XRCC3

Application Details

Application Notes: WB: Use at a dilution of 1/1000. A band of ~40kDa should be detected. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Concentration: 6.2 mg/ml

Purity: Ascitic fluid

Buffer: n/a

Storage: Store at -20 C. Avoid repeated freeze-thaw cycles.

Research Area: Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA

Restrictions: For Research Use only