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C17ORF77 antibody

C17ORF77 Reactivity: Human WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385450
  • Target See all C17ORF77 products
    C17ORF77 (Chromosome 17 Open Reading Frame 77 (C17ORF77))
    Reactivity
    Human
    Host
    • 16
    Rabbit
    Clonality
    • 16
    Polyclonal
    Conjugate
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C17ORF77 antibody is un-conjugated
    Application
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human C17orf77
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    C17ORF77 (Chromosome 17 Open Reading Frame 77 (C17ORF77))
    Alternative Name
    C17orf77 (C17ORF77 Products)
    Synonyms
    chromosome 17 open reading frame 77 antibody, C17orf77 antibody
    Background

    Synonyms: chromosome 17 open reading frame 77, CQ077_HUMAN, hypothetical protein LOC146723, Uncharacterized protein C17orf77.

    Background: C17orf77 is a 243 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

    Gene ID
    146723
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