RNF24 antibody

Catalog No. ABIN1386994

Product Details anti-RNF24 Antibody

Target: RNF24 (Ring Finger Protein 24 (RNF24))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF24 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RNF24

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RNF24

Target: RNF24 (Ring Finger Protein 24 (RNF24))

Alternative Name: RNF24 (RNF24 Products)

Synonyms: G1L antibody, 2810473M14Rik antibody, 4930505A13Rik antibody, AI317164 antibody, C86507 antibody, D2Ertd504e antibody, ring finger protein 24 antibody, RNF24 antibody, Rnf24 antibody

Background:

Synonyms: G1L, Goliath-like protein C3HC4 type, RING finger protein 24, Rnf24, RNF24_HUMAN.

Background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF24 (ring finger protein 24), also known as Goliath-like protein (C3CH4 type) or G1L, is a single-pass membrane protein found in the Golgi apparatus, consisting of 148 amino acids. RNF24 causes intracellular retention of TRPCs, regulates insertion of TRPCs into the plasma membrane and interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. The RNF24 protein shares similarity with Drosophila Goliath protein and thus, may function as a transcription factor. Multiple transcript variants encoding different isoforms have been found for the RNF24 gene, which maps to human chromosome 20p13.

Gene ID: 11237