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CXCR7 antibody (AA 151-250)

CXCR7 Reactivity: Human, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387536
  • Target See all CXCR7 Antibodies
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Binding Specificity
    • 19
    • 14
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reactivity
    • 100
    • 46
    • 40
    • 8
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 86
    • 13
    • 1
    Rabbit
    Clonality
    • 76
    • 23
    • 1
    Polyclonal
    Conjugate
    • 41
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CXCR7 antibody is un-conjugated
    Application
    • 74
    • 36
    • 35
    • 18
    • 15
    • 15
    • 13
    • 9
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CXCR7/RDC1
    Isotype
    IgG
    Top Product
    Discover our top product CXCR7 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Cao, Song, Ge, Song, Chen, Wu: "MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7." in: Oncology letters, Vol. 15, Issue 1, pp. 453-458, (2018) (PubMed).

  • Target
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    Alternative Name
    CXCR7/RDC1 (CXCR7 Products)
    Synonyms
    CMKOR1 antibody, CXC-R7 antibody, CXCR-7 antibody, CXCR7 antibody, GPR159 antibody, RDC-1 antibody, RDC1 antibody, AW541270 antibody, Cmkor1 antibody, Cxcr7 antibody, Rdc1 antibody, ackr3 antibody, cxcr7 antibody, rdc1 antibody, xcxcr7 antibody, atypical chemokine receptor 3 antibody, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antibody, atypical chemokine receptor 3 L homeolog antibody, ACKR3 antibody, MmrVgp88 antibody, Ackr3 antibody, ackr3.L antibody
    Background

    Synonyms: RDC1, CXCR7, RDC-1, CMKOR1, CXC-R7, CXCR-7, GPR159, Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, ACKR3

    Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

    Gene ID
    57007
    UniProt
    P25106
    Pathways
    Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
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