GABRg1 antibody (AA 65-160)

Catalog No. ABIN1387660

Product Details anti-GABRg1 Antibody

Target: GABRg1 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 1 (GABRg1))

Binding Specificity: AA 65-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRg1 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABRG1/GABA A Receptor gamma 1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GABRg1

Target: GABRg1 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 1 (GABRg1))

Alternative Name: GABRG1/GABA A Receptor gamma 1 (GABRg1 Products)

Synonyms: GabaA antibody, GabaA/BZ antibody, gamma-aminobutyric acid type A receptor gamma1 subunit antibody, gamma-aminobutyric acid type A receptor gamma 1 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 antibody, GABRG1 antibody, Gabrg1 antibody

Background:

Synonyms: GABAA receptor subunit gamma 1, GabaA/BZ, GABRG 1, GABRG1, Gamma aminobutyric acid GABA A receptor subunit gamma 1, Gamma aminobutyric acid A receptor, gamma 1, GBRG1,

Background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory transmitter by increasing a Cl- (chloride) conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. The Gamma subunit of GABAA receptors are important for benzodiazepine binding and modulation of GABA-mediated Cl- current. GABAA R Gamma 1 (gamma-aminobutyric acid (GABA) A receptor, gamma 1), also known as GABRG1, is a 465 amino acid multi-pass membrane protein belonging to the ligand-gated ionic channel (TC 1.A.9) family. GABAA R gamma 1 participates in neurotransmission inhibition and has been linked to alcohol dependence.

Gene ID: 2565

UniProt: Q8N1C3

Pathways: Synaptic Membrane