TOR1A antibody (AA 56-130) (Alexa Fluor 350)

Catalog No. ABIN1391571

Product Details anti-TOR1A Antibody (Alexa Fluor 350)

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Binding Specificity: AA 56-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOR1A antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Torsin A

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TOR1A

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Alternative Name: Torsin A (TOR1A Products)

Synonyms: Dyt1 antibody, DQ2 antibody, DYT1 antibody, torsinA antibody, torsin family 1, member A antibody, torsin family 1 member A antibody, torsin family 1, member A (torsin A) antibody, Tor1a antibody, TOR1A antibody

Background:

Synonyms: DQ2, Dystonia 1, Dystonia 1 protein, Dyt1, Tor1a, Torsin A, Torsin family 1 member A, TOR1A_HUMAN.

Background: A mutation of the DYT1 gene, which codes for TorsinA, has been identified as the cause of one form of autosomal dominantly inherited dystonia. Early-onset torsion dystonia is a movement disorder, characterized by twisting muscle contractures, that begins in childhood. Symptoms are believed to result from altered neuronal communication in the basal ganglia. TorsinA comprises 332 amino acids. TorsinA is widely expressed throughout the mouse central nervous system and is detected in the majority of neurons in nearly all regions. The proteins display cytoplasmic distribution, although in some types of neurons localization is perinuclear. TorsinA often performs chaperone-like functions that assist in the assembly, operation, or dis-assembly of protein complexes. The gene which encodes TorsinA has high homology to three additional mammalian genes and a nematode gene and distal similarity to the family of heat-shock proteins and the Clp protease family. The gene which encodes TorsinA maps to human chromosome 9q34.

Pathways: SARS-CoV-2 Protein Interactome