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Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Subcellular location: Extracellular
Synonyms: Sn1-specific diacylglycerol lipase alpha, DGL-alpha, Neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR