Calcyphosine antibody (AA 101-189) (Alexa Fluor 488)

Catalog No. ABIN1395514

Product Details anti-Calcyphosine Antibody (Alexa Fluor 488)

Target: Calcyphosine (CAPS)

Binding Specificity: AA 101-189

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcyphosine antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calcyphosine 1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calcyphosine

Target: Calcyphosine (CAPS)

Alternative Name: Calcyphosine 1/CAPS1 (CAPS Products)

Synonyms: CAPS1 antibody, Caps antibody, Caps1 antibody, Caps2 antibody, caps1 antibody, MGC84373 antibody, CAPS antibody, calcyphosine antibody, calcium dependent secretion activator antibody, calcyphosine S homeolog antibody, CAPS antibody, Cadps antibody, caps.S antibody, caps antibody, Caps antibody

Background:

Synonyms: Calcyphosin, Calcyphosine 1, Calcyphosine, CAPS, CAPS1, CAYP1_HUMAN, Thyroid protein p24.

Background: CAPS1 is a 189 amino acid cytoplasmic protein that contains four EF-hand domains, which serve as calcium-binding sites, and was first identified in canine thyroid. Interestingly, CAPS1 is much less abundant in humans than in canines. Synthesis and phosphorylation of CAPS1 is upregulated by cAMP-agonists in thyrocytes. CAPS1 likely functions in the regulation of ionic transport and may be involved in cross-signaling between cAMP and Ca(+2)-phophatidylinositol cascades. In addition to thyriod, CAPS1 is expressed in brain, salivary glands and lung. Expression of CAPS1 is increased in endometrial cancer and prognosis seems to be dependent on the level of CAPS1 expression, indicating that CAPS1 may be an appropriate prognostic marker for patient survival.