CDC14A antibody (AA 51-150) (Alexa Fluor 488)

Catalog No. ABIN1400020

Product Details anti-CDC14A Antibody (Alexa Fluor 488)

Target: CDC14A (CDC14 Cell Division Cycle 14 Homolog A (CDC14A))

Binding Specificity: AA 51-150

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC14A antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cdc14A

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDC14A

Target: CDC14A (CDC14 Cell Division Cycle 14 Homolog A (CDC14A))

Alternative Name: Cdc14A (CDC14A Products)

Synonyms: cdc14 antibody, hCDC14 antibody, xcdc14a antibody, A830059A17Rik antibody, CDC14A2 antibody, CDC14a1 antibody, Cdc14 antibody, CDC14A antibody, zgc:63654 antibody, cell division cycle 14A antibody, Dual specificity protein phosphatase CDC14A antibody, dual specificity protein phosphatase CDC14A antibody, cell division cycle 14A L homeolog antibody, CDC14 cell division cycle 14A antibody, cell division cycle 14Aa antibody, CDC14A antibody, TVAG_168700 antibody, TVAG_479730 antibody, TVAG_362610 antibody, TVAG_490830 antibody, GL50803_9270 antibody, CMU_014610 antibody, cdc14a.L antibody, Cdc14a antibody, cdc14a antibody, cdc14aa antibody

Background:

Synonyms: CDC 10, Cdc 14, Cdc 14A, Cdc 14A1, Cdc 14A2, CDC10, Cdc14, CDC14 cell division cycle 14 homolog A, CDC14 homolog A, Cdc14A1, Cdc14A2, Cell division cycle 14 homolog A, Dual specicity protein phosphatase CDC 14A, Dual specicity protein phosphatase CDC14A, hCDC14, CC14A_HUMAN.

Background: In budding yeast, the Cdc14a phosphatase activates mitotic exit by dephosphorylation of specific cyclin-dependent kinase (Cdk) substrates and seems to be regulated by sequestration in the nucleolus until its release during mitosis. Human Cdc14a phosphatase is highly similar to Saccharomyces cerevisiae Cdc14 and is a member of the dual specificity protein Tyrosine phosphatase family. It interacts with and dephosphorylates tumor suppressor protein p53 and may regulate the function of p53. In addition, Cdc14a dephosphorylates hCdh1 and activates APCCdh1. Cdc14a phosphatase plays a role in the regulation of the centrosome cycle, mitosis and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. Deregulated human Cdc14a phosphatase disrupts centrosome separation and chromosome segregation.

Gene ID: 8556

UniProt: Q9UNH5