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ZNRF2 antibody (FITC)

ZNRF2 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1401068
  • Target See all ZNRF2 Antibodies
    ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))
    Reactivity
    • 34
    • 27
    • 25
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 33
    • 1
    Rabbit
    Clonality
    • 26
    • 8
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZNRF2 antibody is conjugated to FITC
    Application
    • 23
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ZNRF2
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))
    Alternative Name
    ZNRF2 (ZNRF2 Products)
    Synonyms
    RNF202 antibody, 1190002C14Rik antibody, AU044205 antibody, D6Ertd365e antibody, zgc:152865 antibody, znrf2 antibody, Znrf1 antibody, zgc:171663 antibody, zinc and ring finger 2 antibody, zinc and ring finger 2b antibody, zinc and ring finger 2a antibody, ZNRF2 antibody, Znrf2 antibody, znrf2b antibody, znrf2a antibody
    Background

    Synonyms: E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, Znrf2, ZNRF2_HUMAN.

    Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

    Gene ID
    223082
    Pathways
    Synaptic Membrane
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