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ALAS1 antibody (Alexa Fluor 350)

ALAS1 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1403241
  • Target See all ALAS1 Antibodies
    ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))
    Reactivity
    • 45
    • 21
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 43
    • 2
    Rabbit
    Clonality
    • 32
    • 13
    Polyclonal
    Conjugate
    • 21
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This ALAS1 antibody is conjugated to Alexa Fluor 350
    Application
    • 31
    • 12
    • 9
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ALAS1/ALAS-H
    Isotype
    IgG
    Top Product
    Discover our top product ALAS1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))
    Alternative Name
    ALAS1 (ALAS1 Products)
    Synonyms
    ALAS antibody, ALAS3 antibody, ALASH antibody, MIG4 antibody, ALAS-N antibody, Alas-1 antibody, Alas-h antibody, ALAS-H antibody, ALASN antibody, ALAS1 antibody, wu:fb58d01 antibody, wu:fi12g09 antibody, 5'-aminolevulinate synthase 1 antibody, aminolevulinic acid synthase 1 antibody, alanyl-tRNA synthetase protein antibody, aminolevulinate, delta-, synthase 1 antibody, ALAS1 antibody, Alas1 antibody, alas1 antibody, alas1.S antibody, alaS1 antibody
    Background

    Synonyms: mitochondrial, nonspecic, 5 aminolevulinate synthase, 5 aminolevulinate synthase nonspecic mitochondrial, 5 aminolevulinic acid synthase, 5-aminolevulinate synthase, 5-aminolevulinic acid synthase 1, Alas 1, ALAS 3, ALAS, ALAS H, ALAS N, ALAS-H, alaS1, ALAS3, ALASH, Aminolevulinate delta synthase 1, Aminolevulinic acid synthase 1, Delta ALA synthetase, Delta aminolevulinate synthase, Delta-ALA synthase 1, Delta-aminolevulinate synthase 1, HEM1_HUMAN, MIG 4, MIG4, Migration inducing protein 4.

    Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

    Gene ID
    211
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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