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PCGF2 antibody (AA 170-210) (FITC)

PCGF2 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1404008
  • Target See all PCGF2 Antibodies
    PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))
    Binding Specificity
    • 14
    • 8
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-210
    Reactivity
    Human, Mouse, Rat
    Host
    • 38
    • 2
    • 1
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 14
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCGF2 antibody is conjugated to FITC
    Application
    • 36
    • 20
    • 12
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MEL18
    Isotype
    IgG
    Top Product
    Discover our top product PCGF2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))
    Alternative Name
    MEL18 (PCGF2 Products)
    Synonyms
    ZNF144 antibody, PCGF2 antibody, MEL-18 antibody, RNF110 antibody, Mel18 antibody, Rnf110 antibody, Zfp144 antibody, mel-18 antibody, polycomb group ring finger 2 antibody, PCGF2 antibody, Pcgf2 antibody
    Background

    Synonyms: MEL-18, RNF110, ZNF144, Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18

    Background: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

    Gene ID
    7703
    UniProt
    P35227
    Pathways
    Chromatin Binding
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