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MYLK2 antibody (Alexa Fluor 350)

MYLK2 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1405119
  • Target See all MYLK2 Antibodies
    MYLK2 (Myosin Light Chain Kinase 2 (MYLK2))
    Reactivity
    Human, Mouse, Rat
    Host
    • 21
    • 3
    Rabbit
    Clonality
    • 23
    • 1
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYLK2 antibody is conjugated to Alexa Fluor 350
    Application
    • 24
    • 12
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MYLK2
    Isotype
    IgG
    Top Product
    Discover our top product MYLK2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MYLK2 (Myosin Light Chain Kinase 2 (MYLK2))
    Alternative Name
    MYLK2 (MYLK2 Products)
    Synonyms
    KMLC antibody, MLCK antibody, MLCK2 antibody, skMLCK antibody, 9830004H17Rik antibody, BB138278 antibody, Klmc antibody, Mlck antibody, myosin light chain kinase 2 antibody, myosin, light polypeptide kinase 2, skeletal muscle antibody, MYLK2 antibody, Mylk2 antibody, mylk2 antibody
    Background

    Synonyms: KMLC, MLCK, MLCK2, MYLK 2, Myosin light chain kinase 2, Myosin light chain kinase 2 skeletal muscle, Myosin light chain kinase 2 skeletal/cardiac muscle, Skeletal muscle myosin light chain kinase, Skeletal myosin light chain kinase, skMLCK, MYLK2_HUMAN.

    Background: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII, CaMKIV and myosin light chain kinases (MYLK, also designated MLCK). The MYLK kinases phosphorylate myosin regulatory light chains to catalyze myosin interaction with actin filaments resulting in contractile activity. Non-muscle, smooth muscle and skeletal/cardiac muscle MYLK isoforms exist. The MYLK gene (also designated MYLK1) encodes both smooth muscle and non-muscle isoforms as well as telokin, a small C-terminal isoform expressed only in smooth muscle with the capacity to stabilize unphosphorylated myosin filaments. Multiple transcript variants are described for the MYLK gene. Smooth-muscle and non-muscle MYLK isoforms are expressed in a wide variety of adult and fetal tissues. The skeletal/cardiac muscle isoforms of MYLK are encoded by a separate gene, MYLK2 (also designated skMLCK). MYLK appears to be a target for PAKs (p21-activated kinases). PAK1 interaction with MYLK results in a decrease in MYLK activity and myosin light chain phosphorylation.

    Gene ID
    85366
    Pathways
    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation
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