CLEC11A antibody (Alexa Fluor 488)

Catalog No. ABIN1405336

Product Details anti-CLEC11A Antibody (Alexa Fluor 488)

Target: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLEC11A antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Pleckstrin/p47

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLEC11A

Target: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Alternative Name: p47 (CLEC11A Products)

Synonyms: CLEC11A antibody, CLECSF3 antibody, LSLCL antibody, P47 antibody, SCGF antibody, AW457320 antibody, Clecsf3 antibody, Scgf antibody, C-type lectin domain containing 11A antibody, C-type lectin domain family 11, member a antibody, CLEC11A antibody, Clec11a antibody

Background:

Synonyms: p47, Platelet 47 kDa protein, Platelet and leukocyte C kinase substrate, Platelet P47, Platelet p47 protein, Pleckstrin, PLEK, PLEK_HUMAN, FLJ27168, OTTHUMP00000159962.

Background: Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89 % sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.

Gene ID: 5341