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LEFTY1 antibody (AA 51-150) (Cy5.5)

LEFTY1 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Cy5.5
Catalog No. ABIN1407971
  • Target See all LEFTY1 Antibodies
    LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
    Binding Specificity
    • 14
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivity
    • 45
    • 12
    • 9
    Human
    Host
    • 51
    • 7
    • 1
    Rabbit
    Clonality
    • 52
    • 7
    Polyclonal
    Conjugate
    • 29
    • 10
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LEFTY1 antibody is conjugated to Cy5.5
    Application
    • 40
    • 18
    • 17
    • 12
    • 12
    • 9
    • 9
    • 4
    • 4
    • 4
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Lefty
    Isotype
    IgG
    Top Product
    Discover our top product LEFTY1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
    Alternative Name
    Lefty (LEFTY1 Products)
    Synonyms
    atv antibody, cb73 antibody, antivin antibody, ik:tdsubc_2b12 antibody, xx:tdsubc_2b12 antibody, LEFTY1 antibody, AI450052 antibody, Ebaf antibody, Leftb antibody, Stra3 antibody, Tgfb4 antibody, lefty antibody, lefty-1 antibody, RGD1561867 antibody, LEFTB antibody, LEFTYB antibody, lefty1 antibody, signaling molecule lefty1 antibody, left-right determination factor 1 antibody, left right determination factor 1 antibody, lft1 antibody, lefty1 antibody, LOC699924 antibody, LEFTY1 antibody, LOC100408003 antibody, LOC100597378 antibody, Lefty1 antibody
    Background

    Synonyms: Protein lefty-1, AI450052, Ebaf, Left right determination factor 1, left right determination factor, Left right determination factor B, left-right determination factor, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTY1, left-right determination, factor B, LEFT-RIGHT DETERMINATION, FACTOR B, LEFTY B, LEFTB, LEFTY 1, Lefty, lefty-1, LEFTY1, LEFTY1, MOUSE, HOMOLOG OF antibody, LEFTYB, Protein lefty-B, RGD1561867, Stimulated by retinoic acid gene 3 protein, STRA3, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4.

    Background: During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.

    Gene ID
    10637
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