COL25A1 antibody (AA 581-654) (HRP)

Catalog No. ABIN1410380

Product Details anti-COL25A1 Antibody (HRP)

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Binding Specificity: AA 581-654

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL25A1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLACP/COL25A1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COL25A1

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Alternative Name: CLACP/COL25A1 (COL25A1 Products)

Synonyms: COL25A1 antibody, AMY antibody, CLAC antibody, CLAC-P antibody, CLACP antibody, 2700062B08Rik antibody, collagen type XXV alpha 1 chain antibody, collagen, type XXV, alpha 1 antibody, COL25A1 antibody, col25a1 antibody, Col25a1 antibody

Background:

Synonyms: Alzheimer disease amyloid associated protein, AMY, CLAC, CLAC P, CLAC precursor, COL25A1, COL25A1 protein, Collagen alpha 1 XXV chain, Collagen alpha 1XXV chain, Collagen like Alzheimer amyloid plaque component, Collagen like Alzheimer amyloid plaque component precursor, Collagen type XXV alpha 1, Collagenous Alzheimer amyloid plaque component.

Background: Collagen proteins (products of the COL gene family) are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. The Collagen Type XXV precursor produces the proteolytic fragment CLAC (collagenous Alzheimer amyloid plaque component), which deposits in senile plaques associated with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease. CLAC binds to the fibrillized form of Abeta, which disturbs the structure and function of plasma membranes.