Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Add to Basket
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN141329

Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) antibody

Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1, 127kDa, AA408517, p127-Ddb1, DDB1, xpe, ddba, xap1, xpce, xpe-bf, uv-ddb1, ddb1
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN141329
Quantity 0.1 mg
Contact our Customer Service for availability and price in your country.
Shipping to
Immunogen Synthetic peptide conugated to protein carrier.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Affinity purified with antigen.
Alternative Name DDB1 / XAP1
Background The DNA damage-binding protein from HeLa cells is associated with polypeptides of relative mass 124,000 (DDB1) and 41,000 (DDB2) as determined by SDS-polyacrylamide gels. To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, Keeney et al. (1994) injected purified human DDB protein into XPE cells. The injected DDB protein stimulated DNA repair to normal levels in those strains that lacked the DDB activity but did not stimulate repair in cells from XPE patients that contained the activity. These results provided direct evidence that defective DDB activity causes the repair defect in a subset of XPE patients and establishes a role for this activity in nucleotide-excision repair in vivo. It remains for mutation analysis to demonstrate whether the defect in XPE patients is in the DDB1 gene or the DDB2 gene.
Application Notes 1/1000 in PBS/Milk 5%/Tween 0,05%. Incubation OVN at 4 C. Secondary antibody 2 hours at room temperature with dilution 1/5000 in PBS/Milk 5%/Tween 0,05%. ECL.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline, pH 7.2, no preservative added.
Storage -80 °C
Holschneider: "[Current interpretation of the testicular maldescention problem]" in: Tierärztliche Praxis, Vol. 3, Issue 1, pp. 123-7, 1976 (PubMed).

Chu, Chang: "Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA." in: Science (New York, N.Y.), Vol. 242, Issue 4878, pp. 564-7, 1988 (PubMed).

Alternatives for antigen "Damage-Specific DNA Binding Protein 1, 127kDa (DDB1)", type "Antibodies"
Hosts (30), (11), (8)
Reactivities (47), (24), (19), (14), (12), (2), (2)
Applications (38), (24), (14), (10), (8), (6), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (2), (2), (1)