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THO Complex 2 antibody (AA 101-200) (Cy7)

THOC2 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Cy7
Catalog No. ABIN1413936
  • Target See all THO Complex 2 (THOC2) Antibodies
    THO Complex 2 (THOC2)
    Binding Specificity
    • 14
    • 2
    • 2
    AA 101-200
    Reactivity
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 20
    Rabbit
    Clonality
    • 20
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This THO Complex 2 antibody is conjugated to Cy7
    Application
    • 19
    • 12
    • 12
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human THOC2
    Isotype
    IgG
    Top Product
    Discover our top product THOC2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    THO Complex 2 (THOC2)
    Alternative Name
    Thoc2 (THOC2 Products)
    Synonyms
    RGD1561623 antibody, THO antibody, Tho2 antibody, fb73e08 antibody, fd21d11 antibody, wu:fb73e08 antibody, wu:fd21d11 antibody, si:bz1o18.2 antibody, CXorf3 antibody, THO2 antibody, dJ506G2.1 antibody, hTREX120 antibody, 6330441O12Rik antibody, D130005M13Rik antibody, Gm1139 antibody, Gm1793 antibody, THO complex 2 antibody, Thoc2 antibody, THOC2 antibody, thoc2 antibody
    Background

    Synonyms: THO2, CXorf3, hTREX120, dJ506G2.1, THO complex subunit 2, THOC2

    Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.

    Gene ID
    57187
    UniProt
    Q8NI27
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