Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN141540
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Antigen
Synonyms MCP-1, Scya2, Sigje, GDCF-2, HC11, HSMCR30, MCAF, MCP1, SCYA2, SMC-CF, AI323594, JE, MCP-1A, MCP1A
Reactivity
Mouse (Murine), Rat (Rattus)
(238), (99), (80), (8), (8), (6), (6), (5), (5), (5), (4), (1), (1)
Host
Rabbit
(213), (108), (28), (6), (4), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(43), (24), (18), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(279), (215), (71), (41), (40), (35), (31), (28), (28), (21), (17), (16), (12), (10), (6), (5), (2), (1), (1)
Pubmed 4 references available
Quantity 50 μg
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Catalog No. ABIN141540
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Immunogen Recombinant full length protein (Rat)
Isotype IgG
Cross-Reactivity Rat (Rattus)
Purification Protein A purified.
Alternative Name MCP1 / CCL2
Background Rat MCP-1/JE (monocyte chemoattractant protein-1) is a 148-amino acid CC chemokine with a NH2-terminal sequence of 29 residues as a signal sequence. It was originally cloned from Con A-stimulated rat spleen cDNA library. This rat MCP-1/JE is 49-amino acid longer than humanMCP-1 at 3'-end. This 3'-end is a serine and threonine rich zone, which is probably responsible for the extensive O-glycosylation and explains for the higher molecular weight (25 kDa). In vitro, MCP-1/JE is chemotactic for monocytes as well as lymphocytes and basophils, but not for neutrophils. MCP-1/JE is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli.
Synonyms: MCP-1 , Scya2 , Sigje , MCP 1
Research Area Cytokines, Chemokines
Application Notes WB: Use at a dilution of 1:2,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline containing 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
General Yoshimura, Takeya, Takahashi: "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines." in: Biochemical and biophysical research communications, Vol. 174, Issue 2, pp. 504-9, 1991 (PubMed).

Rollins, Stier, Ernst et al.: "The human homolog of the JE gene encodes a monocyte secretory protein." in: Molecular and cellular biology, Vol. 9, Issue 11, pp. 4687-95, 1990 (PubMed).

Haelens, Wuyts, Proost et al.: "Leukocyte migration and activation by murine chemokines." in: Immunobiology, Vol. 195, Issue 4-5, pp. 499-521, 1997 (PubMed).

Porter, Khanna, Kaminski et al.: "A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice." in: Human molecular genetics, Vol. 11, Issue 3, pp. 263-72, 2002 (PubMed).

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