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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN141540, Supplier: Login to see
Antigen
  • MCP-1
  • Scya2
  • Sigje
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP1
  • SCYA2
  • SMC-CF
  • AI323594
  • JE
  • MCP-1A
  • MCP1A
Reactivity
Mouse (Murine), Rat (Rattus)
311
102
84
15
12
11
8
8
6
6
5
5
4
1
1
Host
Rabbit
265
147
25
8
8
8
6
Clonality
Polyclonal
Conjugate
Un-conjugated
64
34
22
10
5
3
2
2
2
2
1
1
1
Application
Western Blotting (WB)
326
271
85
57
54
46
31
30
30
26
25
24
7
6
5
5
4
3
3
3
3
2
2
1
Supplier
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Immunogen Recombinant full length protein (Rat)
Isotype IgG
Cross-Reactivity Rat (Rattus)
Purification Protein A purified.
Alternative Name MCP1 / CCL2 (CCL2 Antibody Abstract)
Background Rat MCP-1/JE (monocyte chemoattractant protein-1) is a 148-amino acid CC chemokine with a NH2-terminal sequence of 29 residues as a signal sequence. It was originally cloned from Con A-stimulated rat spleen cDNA library. This rat MCP-1/JE is 49-amino acid longer than humanMCP-1 at 3'-end. This 3'-end is a serine and threonine rich zone, which is probably responsible for the extensive O-glycosylation and explains for the higher molecular weight (25 kDa). In vitro, MCP-1/JE is chemotactic for monocytes as well as lymphocytes and basophils, but not for neutrophils. MCP-1/JE is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli.
Synonyms: MCP-1 , Scya2 , Sigje , MCP 1
Research Area Cytokines, Chemokines
Pathways
Application Notes WB: Use at a dilution of 1:2,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline containing 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
Western Blotting (WB) image for anti-Chemokine (C-C Motif) Ligand 2 (CCL2) antibody (ABIN141540) anti-Chemokine (C-C Motif) Ligand 2 (CCL2) antibody
Background publications Porter, Khanna, Kaminski et al.: "A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice." in: Human molecular genetics, Vol. 11, Issue 3, pp. 263-72, 2002 (PubMed).

Haelens, Wuyts, Proost et al.: "Leukocyte migration and activation by murine chemokines." in: Immunobiology, Vol. 195, Issue 4-5, pp. 499-521, 1997 (PubMed).

Rollins, Stier, Ernst et al.: "The human homolog of the JE gene encodes a monocyte secretory protein." in: Molecular and cellular biology, Vol. 9, Issue 11, pp. 4687-95, 1990 (PubMed).

Yoshimura, Takeya, Takahashi: "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines." in: Biochemical and biophysical research communications, Vol. 174, Issue 2, pp. 504-9, 1991 (PubMed).