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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN141540
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Antigen
Synonyms GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, JE, Scya2, Sigje, AI323594, MCP-1A, MCP1A
Reactivity
Mouse (Murine)
(202), (96), (87), (17), (17), (17), (11), (7), (4), (2), (2), (2), (1), (1)
Host
Rabbit
(190), (103), (21), (9), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(35), (19), (12), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(246), (221), (75), (49), (40), (36), (32), (32), (20), (19), (18), (16), (5), (4), (2), (1), (1)
Pubmed 4 references available
Quantity 50 µg
Shipping to United States (Change)
Catalog No. ABIN141540
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Recombinant full length protein (Rat)
Isotype IgG
Cross-Reactivity Rat (Rattus)
Purification Protein A affinity purified
Alternative Name MCP1 / CCL2
Background Rat MCP-1/JE (monocyte chemoattractant protein-1) is a 148-amino acid CC chemokine with a NH2-terminal sequence of 29 residues as a signal sequence. It was originally cloned from Con A-stimulated rat spleen cDNA library (ref 1). This rat MCP-1/JE is 49-amino acid longer than humanMCP-1 at 3-end. This 3-end is a serine and threonine rich zone, which is probably responsible for the extensive O-glycosylation and explains for the higher molecular weight (25 kDa) (ref 3). In vitro, MCP-1/JE is chemotactic for monocytes as well as lymphocytes and basophils, but not for neutrophils. MCP-1/JE is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli (ref 3).
Research Area Cytokines, Chemokines
Application Notes WB: Use at a dilution of 1:2,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate-buffered saline containing 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Yoshimura, Takeya, Takahashi: "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines." in: Biochemical and biophysical research communications, Vol. 174, Issue 2, pp. 504-9, 1991 (PubMed).

Rollins, Stier, Ernst et al.: "The human homolog of the JE gene encodes a monocyte secretory protein." in: Molecular and cellular biology, Vol. 9, Issue 11, pp. 4687-95, 1990 (PubMed).

Haelens, Wuyts, Proost et al.: "Leukocyte migration and activation by murine chemokines." in: Immunobiology, Vol. 195, Issue 4-5, pp. 499-521, 1997 (PubMed).

Porter, Khanna, Kaminski et al.: "A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice." in: Human molecular genetics, Vol. 11, Issue 3, pp. 263-72, 2002 (PubMed).

Hosts (190), (103), (21), (9), (5), (3)
Reactivities (202), (96), (87), (17), (17), (17), (11), (7), (4), (2), (2), (2), (1), (1)
Applications (246), (221), (75), (49), (40), (36), (32), (32), (20), (19), (18), (16), (5), (4), (2), (1), (1)
Conjugates (35), (19), (12), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (9), (9), (7), (7), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN141540
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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