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C21ORF45 antibody (HRP)

MIS18A Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal HRP
Catalog No. ABIN1422250
  • Target See all C21ORF45 (MIS18A) Antibodies
    C21ORF45 (MIS18A) (MIS18 Kinetochore Protein Homolog A (MIS18A))
    Reactivity
    • 17
    • 16
    • 15
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 17
    Rabbit
    Clonality
    • 17
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C21ORF45 antibody is conjugated to HRP
    Application
    • 17
    • 13
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FASP1/C21orf45
    Isotype
    IgG
    Top Product
    Discover our top product MIS18A Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    C21ORF45 (MIS18A) (MIS18 Kinetochore Protein Homolog A (MIS18A))
    Alternative Name
    FASP1 (MIS18A Products)
    Synonyms
    B28 antibody, C21orf45 antibody, C21orf46 antibody, FASP1 antibody, MIS18alpha antibody, hMis18alpha antibody, 2610039C10Rik antibody, 2810018N07Rik antibody, RGD1310778 antibody, MIS18 kinetochore protein A antibody, MIS18A antibody, Mis18a antibody
    Background

    Synonyms: B28, C21orf46, FASP1, hMis18alpha, MaFF interacting protein, MAFIP, MIS18A, Protein Mis18 alpha, MS18A_HUMAN.

    Background: Mapping to chromosome 21, the FASP1 gene (FAPP1-associated protein 1) encodes a 233 amino acid protein that is homologous to the fission yeast protein Mis18. In yeast, Mis18 is localized to the centrosome and forms a complex with Mis16 to maintain the deacetylated state of histones specifically in the central core of centromeres. FASP1, also known as Protein Mis18-alpha and C21orf45, is required for the recruitment of CENP-A to centrosomes and is thereby essential for normal chromosome segregation during mitosis. With expression in testis, FASP1 exists as a homodimer, a heterodimer with MIS18B or is present in a complex containing other Mis18 family members. FASP1 has been shown to bind to pp5644 in Hela cells, where overexpression of pp5644 leads to inhibited growth and colony formation.

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