SERPINE2 antibody (AA 301-398) (HRP)

Catalog No. ABIN1422868

Product Details anti-SERPINE2 Antibody (HRP)

Target: SERPINE2 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 (SERPINE2))

Binding Specificity: AA 301-398

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINE2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GDN/SERPINE2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SERPINE2

Target: SERPINE2 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 (SERPINE2))

Alternative Name: GDN (SERPINE2 Products)

Synonyms: GDN antibody, GDNPF antibody, PI-7 antibody, PI7 antibody, PN-1 antibody, PN1 antibody, PNI antibody, SERPINE2 antibody, MGC143011 antibody, Gdnpn1 antibody, Pn-1 antibody, Spin4 antibody, B230326M24Rik antibody, PAI-1 antibody, Spi4 antibody, zgc:55929 antibody, serpin family E member 2 antibody, serine (or cysteine) peptidase inhibitor, clade E, member 2 antibody, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 antibody, SERPINE2 antibody, serpine2 antibody, Serpine2 antibody

Background:

Synonyms: Glia derived nexin, Protease inhibitor 7, GDN, GDN_HUMAN, Glia-derived nexin, P17 antibody Peptidase inhibitor 7, Pi-7, Plasminogen activator inhibitor type 1, member 2, PN-1, PN1, PNI, Protease nexin 1, Protease nexin I, Serpin E2, Serpin peptidase inhibitor, clade E nexin, plasminogen activator inhibitor type 1, member 2, SERPINE 2, Serpine2.

Background: The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer??s disease.

Gene ID: 5270

UniProt: P07093