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Cell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) antibody

Details for Product No. ABIN142551, Supplier: Login to see
Antigen
Reactivity
Human
55
35
31
2
1
1
Host
Mouse
45
10
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
40
12
11
11
9
8
7
3
Supplier
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Immunogen Full-length human Cdc34 expressed in E. coli.
Isotype IgG
Characteristics Cellular Localization: Nuclear
Purification Unpurified. From polyclonal serum.
Alternative Name CDC34 (CDC34 Antibody Abstract)
Background Cdc34 is a ubiquitin conjugating enzyme (UBC) or E2 that has been shown to be essential for the G1 to S phase transition in S. cerevisiae. Human Cdc34 fully complements the budding yeast Cdc34 temperature sensitive mutant phenotype. In egg extracts of the frog Xenopus laevis, Cdc34 has been shown to be required for the onset of DNA replication and appears to function in a multi-protein complex. Also, Cdc34 is highly conserved among vertebrates and is likely to function in a similar manner in all eukaryotes to regulate the start of DNA synthesis.
Synonyms: 116948, 997, CDC34, UBE2R1, P49427, E2CDC34, E2-CDC34, E2 CDC34
Research Area Cell Cycle, CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Comment

Positive Controls: 293

Restrictions For Research Use only
Format Liquid
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Background publications Koepp, Harper, Elledge: "How the cyclin became a cyclin: regulated proteolysis in the cell cycle." in: Cell, Vol. 97, Issue 4, pp. 431-4, 1999 (PubMed).

Tyers, Willems: "One ring to rule a superfamily of E3 ubiquitin ligases." in: Science (New York, N.Y.), Vol. 284, Issue 5414, pp. 601, 603-4, 1999 (PubMed).

Goebl, Yochem, Jentsch et al.: "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme." in: Science (New York, N.Y.), Vol. 241, Issue 4871, pp. 1331-5, 1988 (PubMed).