Ataxia Telangiectasia and Rad3 Related (ATR) (C-Term), (AA 2122-2644) antibody

Details for Product No. ABIN143628
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Antigen
Synonyms
ATR, si:dkey-231j24.1, FCTCS, FRP1, MEC1, SCKL, SCKL1, XATR, frp1, mec1, sckl, sckl1, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, ATRAD3, Ataxia telangiectasia-mutated  ... show more
ATR, si:dkey-231j24.1, FCTCS, FRP1, MEC1, SCKL, SCKL1, XATR, frp1, mec1, sckl, sckl1, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, ATRAD3, Ataxia telangiectasia-mutated and RAD3-related, MHK7.5, MHK7_5 show less
Epitope
C-Term, AA 2122-2644
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(21), (6), (3), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(16), (6)
Clonality
Polyclonal
Application
Western Blotting (WB)
(16), (6), (6), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 μL
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Catalog No. ABIN143628
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Immunogen The carboxy-terminal portion of human ATR protein (amino acids 2122-2644).
Isotype IgG
Cross-Reactivity Mouse (Murine), Hamster
Purification Unpurified. Antiserum
Alternative Name ATR / FRP1
Background Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.
Synonyms: SCKL1, Q13535, ATR, 210600, MEC1, FRP1, SCKL, 545
Application Notes Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Restrictions For Research Use only
Format Liquid
Buffer Contains 0.09% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
General Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).

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