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Details for Product No. ABIN143811

Catenin beta-1 (CTNB1) antibody

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Antigen
Synonyms Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, CHBCAT
Reactivity
»Alternatives Cow (Bovine)
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN143811
Quantity 0.1 mL
Price
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Immunogen Recombinant full length protein (Chicken).
Isotype IgG1
Specificity Recognises beta-catenin (94kD) in immunoblotting. Does not cross-react with plakoglobin.
Cross-Reactivity Dog (Canine), Human
Purification Ascites
Alternative Name Catenin beta-1
Background The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 protooncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Research Area Signaling
Application Notes ICC: Use at an assay dependant dilution. IF: Use at a dilution of 1/1000. WB: Use at a dilution of 1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid with 0.1% sodium azide
Preservative Sodium azide
Storage 4 °C
Edelman, Crossin: "Cell adhesion molecules: implications for a molecular histology." in: Annual review of biochemistry, Vol. 60, pp. 155-90, 1991 (PubMed).

Takeichi: "Cadherin cell adhesion receptors as a morphogenetic regulator." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1451-5, 1991 (PubMed).

Nagafuchi, Takeichi: "Cell binding function of E-cadherin is regulated by the cytoplasmic domain." in: The EMBO journal, Vol. 7, Issue 12, pp. 3679-84, 1989 (PubMed).

Reynolds, Daniel, McCrea et al.: "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8333-42, 1994 (PubMed).

Tsukita, Itoh, Nagafuchi et al.: "Submembranous junctional plaque proteins include potential tumor suppressor molecules." in: The Journal of cell biology, Vol. 123, Issue 5, pp. 1049-53, 1994 (PubMed).

Johnson, Lewis, Li et al.: "P- and E-cadherin are in separate complexes in cells expressing both cadherins." in: Experimental cell research, Vol. 207, Issue 2, pp. 252-60, 1993 (PubMed).

Alternatives for antigen "Catenin beta-1 (CTNB1)", type "Antibodies"
Hosts (462), (147), (2), (1)
Reactivities (574), (324), (305), (192), (161), (116), (14), (8), (6), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (446), (173), (151), (140), (117), (95), (71), (55), (40), (22), (8), (5), (3), (1), (1), (1), (1)
Conjugates (19), (16), (16), (15), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Epitopes (55), (53), (49), (43), (43), (28), (20), (16), (15), (15), (13), (12), (9), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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