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Kinesin Family Member 5B (KIF5B) antibody

Details for Product No. ABIN143825
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Antigen
Synonyms Khc, KIF5A, KINH, KNS, KNS1, UKHC, AL022807, Khcs, Kns1, Ukhc, khc
Reactivity
Human
(40), (14), (14), (11), (11), (10), (2), (2), (2), (2)
Host
Mouse
(24), (24), (10)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(44), (27), (18), (16), (13), (11), (9), (4), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN143825
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Immunogen Full length native protein (purified) (Pig).
Isotype IgM
Specificity Reacts with conventional kinesin associated with vesicles and with lower affinity with denaturated molecule. This antibody recognizes the heavy chain of kinesin.No cross-reaction with the light chain of the molecule nor with other proteins was detected.
Cross-Reactivity Mouse (Murine)
Purity > 95 % by SDS-PAGE
Alternative Name KIF5B
Background Kinesin belongs to the group of motor proteins known to convert chemical energy released from ATP into mechanical energy. Conventional kinesin, member of the kinesin superfamily comprising more than 100 proteins, is involved in the anterograde vesicle transport in neuronal cells. Kinesin purified from mammalian brain homogenates is a heterotetramer consisting of two heavy (120 to 130 kDa) and two light chains (60 to 70 kDa), resulting in a molecular mass about 400 kDa. Each heavy chain contains an N-terminal globular motor domain with both a microtubule-binding site and an ATPase active center, stalk region responsible for heavy chain dimerization and finally C-terminal globular tail domain, which is implicated in cargo binding. Light chains may have a regulatory function.
Research Area Cytoskeleton
Application Notes ICC: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Only with kinesin-enriched preparations. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Stein: "The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1659-62, 1976 (PubMed).

Kelkar, Delmotte, Weston et al.: "Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 9843-8, 2003 (PubMed).

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