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MAP2K7 antibody (Mitogen-Activated Protein Kinase Kinase 7)

Details for Product anti-MAP2K7 Antibody No. ABIN1449156, Supplier: Login to see New
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Antigen
Alternatives
Reactivity
Mouse (Murine)
(126), (64), (53), (1), (1), (1)
Host
Rat
(115), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
This MAP2K7 antibody is un-conjugated
(5), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(117), (73), (42), (18), (16), (11), (11), (6), (6), (5), (2), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability
Immunogen GST-mouse MKK7 fusion protein corresponding to full length amino acids
Clone KN-004
Isotype IgG2a
Specificity This antibody reacts with MKK7. It reacts with all of MKK7 isoforms.
Cross-Reactivity (Details) Species reactivity (tested):Mouse
Purification Protein-G Sepharose
Alternative Name MAP2K7 (MAP2K7 Antibody Abstract)
Background MKK7 (Mitogen-activated protein kinase kinase 7) is a stress-activated member of the MKK family that phosphorylates and activates JNK (c-Jun NH2-terminal kinase/SAPK). MKK7 is specific for JNK and does not appear to phosphorylate either the ERK or p38 members of the MAP kinase family. MKK7 is strongly activated by TNFa or MEK kinase-3, and may also be activated by many factors including heat, UV, CD40 ligation, hyperosmolarity, Fas, or IL-3. Alternately, the Map kinase phosphatase, SKRP1, suppresses JNK activation via MKK7. The 47 kDa MKK7 protein is ubiquitously expressed and highly conserved among various species.Synonyms: Dual specificity mitogen-activated protein kinase kinase 7, JNK-activating kinase 2, MAP kinase kinase 7, MAPK/ERK kinase 7, MAPKK 7, MEK7, MKK7, NKK2, c-Jun N-terminal kinase kinase 2
Gene ID 26400
NCBI Accession NP_001036022
UniProt Q8CE90
Research Area Kinases/Phosphatases
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MAP2K7 antibody (Mitogen-Activated Protein Kinase Kinase 7) (ABIN1449156) anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) antibody
Background publications Wada, Nakagawa, Watanabe et al.: "Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30892-7, 2001 (PubMed).

Catalog No. ABIN1449156

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