anti-MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4)

Details for Product anti-MAP2K4 Antibody No. ABIN1449157
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Human, Mouse (Murine)
(343), (163), (139), (5), (4), (4), (2), (2)
(307), (44)
Clonality (Clone)
Monoclonal ()
This MAP2K4 antibody is un-conjugated
(13), (13), (12), (8), (8), (8), (3), (3), (3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(223), (159), (116), (72), (53), (30), (25), (17), (14), (13), (12), (4), (3), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Immunogen Recombinant full length mouse MKK4 protein
Clone KN-001
Isotype IgG2a
Specificity This antibody reacts with SEK1/MKK4.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Protein G agarose
Alternative Name MAP2K4 (MAP2K4 Antibody Abstract)
Background MKK4 (Mitogen-activated protein kinase kinase 4) is a stress-activated member of the MKK family that phosphorylates and activates JNK (c-Jun NH2-terminal kinase/SAPK). This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 is specific for JNK and does not appear to phosphorylate either the ERK or p38 members of the MAP kinase family. MKK4 is strongly activated by TNFa or MEK kinase-3, and may also be activated by many factors including heat, UV, CD40 ligation, hyperosmolarity, Fas, or IL-3. The MKK4 protein is ubiquitously expressed and highly conserved among various species.Synonyms: Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAP Kinase Kinase 4, MAPKK4, MEK-4, MKK4, PRKMK4, SAPK/ERK kinase 1, SERK1, c-Jun N-terminal kinase kinase 1
Gene ID 6416
NCBI Accession NP_003001
UniProt P45985
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4) (ABIN1449157) anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody
Background publications Wada, Nakagawa, Watanabe et al.: "Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30892-7, 2001 (PubMed).

Catalog No. ABIN1449157
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