Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN1449157

Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Sek1, Serk1, MKK4A-l, map2k4, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, C ... show more
Reactivity
»Alternatives Human, Mouse (Murine)
Host
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN1449157
Quantity 0.1 mg
Price
275.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant full length mouse MKK4 protein
Clone KN-001
Isotype IgG2a
Specificity This antibody reacts with SEK1/MKK4.
Purification Protein G agarose
Alternative Name MAP2K4
Background MKK4 (Mitogen-activated protein kinase kinase 4) is a stress-activated member of the MKK family that phosphorylates and activates JNK (c-Jun NH2-terminal kinase/SAPK). This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 is specific for JNK and does not appear to phosphorylate either the ERK or p38 members of the MAP kinase family. MKK4 is strongly activated by TNFa or MEK kinase-3, and may also be activated by many factors including heat, UV, CD40 ligation, hyperosmolarity, Fas, or IL-3. The MKK4 protein is ubiquitously expressed and highly conserved among various species.
Alternate names: Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAP Kinase Kinase 4, MAPKK4, MEK-4, MKK4, PRKMK4, SAPK/ERK kinase 1, SERK1, c-Jun N- terminal kinase kinase 1
Gene ID 6416
NCBI Accession NP_003001.1
UniProt P45985
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Wada, Nakagawa, Watanabe et al.: "Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30892-7, 2001 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)", type "Antibodies"
Hosts (197), (25)
Reactivities (220), (151), (144), (60), (52), (48), (36), (12), (2), (1)
Applications (122), (72), (71), (58), (50), (32), (12), (9), (6), (5), (3), (2), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (51), (38), (34), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Beacon