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Details for Product No. ABIN1449157

Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody

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JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Sek1, Serk1, MKK4A-l, map2k4, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, C ... show more
»Alternatives Human, Mouse (Murine)
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN1449157
Quantity 0.1 mg
275.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant full length mouse MKK4 protein
Clone KN-001
Isotype IgG2a
Specificity This antibody reacts with SEK1/MKK4.
Purification Protein G agarose
Alternative Name MAP2K4
Background MKK4 (Mitogen-activated protein kinase kinase 4) is a stress-activated member of the MKK family that phosphorylates and activates JNK (c-Jun NH2-terminal kinase/SAPK). This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 is specific for JNK and does not appear to phosphorylate either the ERK or p38 members of the MAP kinase family. MKK4 is strongly activated by TNFa or MEK kinase-3, and may also be activated by many factors including heat, UV, CD40 ligation, hyperosmolarity, Fas, or IL-3. The MKK4 protein is ubiquitously expressed and highly conserved among various species.
Alternate names: Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAP Kinase Kinase 4, MAPKK4, MEK-4, MKK4, PRKMK4, SAPK/ERK kinase 1, SERK1, c-Jun N- terminal kinase kinase 1
Gene ID 6416
NCBI Accession NP_003001.1
UniProt P45985
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Wada, Nakagawa, Watanabe et al.: "Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30892-7, 2001 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)", type "Antibodies"
Hosts (197), (25)
Reactivities (220), (151), (144), (60), (52), (48), (36), (12), (2), (1)
Applications (122), (72), (71), (58), (50), (32), (12), (9), (6), (5), (3), (2), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (51), (38), (34), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)