IL12RB1 antibody

Catalog No. ABIN1449166

Product Details anti-IL12RB1 Antibody

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with CD212.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogen: B300-19 cells transfected with the vector expressing an IL-12R beta1/Tac fusion protein

Clone: TOS

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: CD212 / IL12RB1 (IL12RB1 Products)

Synonyms: Il12rb antibody, IL12RB1 antibody, IL-12R antibody, CD212 antibody, IL-12R-BETA1 antibody, IL12RB antibody, IL-12R[b] antibody, interleukin 12 receptor subunit beta 1 antibody, interleukin 12 receptor, beta 1 antibody, Il12rb1 antibody, IL12RB1 antibody

Background: A functional interleukin 12 receptor complex is composed of two ß-type cytokine receptor subunits, IL-12R ß1 (100 kDa) and IL-12R ß2 (130 kDa), each independently exhibiting a low affinity for IL-12. Co-expression leads to the formation of high-affinity IL-12-binding sites and reconstitution of IL-12-dependent signaling. IL-12R ß1 is a member of the hemopoietin receptor superfamily, bearing strong homology to gp130. IL-12 receptors are expressed primarily on activated T cells and natural killer (NK) cells, and activation of human PBMCs results in the up-regulation of IL-12R ß1 expression and IL-12 binding. Alternately, individuals that are genetically deficient in IL-12R ß1 produce greatly reduced IFN-? levels compared to healthy individuals. IL-12 induces tyrosine phosphorylation of an 85 kDa component of the IL-12 receptor complex that associates with the IL-12R ß1 subunit.Synonyms: IL-12 receptor beta, IL-12R-beta-1, IL-12RB1, IL12 receptor beta component, Interleukin-12 receptor beta-1 chain

Gene ID: 3594

NCBI Accession: NP_005526

UniProt: P42701

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation