CD226 antibody (CD226 Molecule)

Details for Product anti-CD226 Antibody No. ABIN1449202, Supplier: Log in to see
Antigen
  • CD226
  • cd226
  • zgc:158817
  • BC051526
  • DNAM-1
  • DNAM1
  • Pta1
  • TLiSA1
  • PTA1
  • CD226 molecule
  • CD226 antigen
  • CD226
  • cd226
  • Cd226
Alternatives
anti-Human CD226 antibody for Functional Studies
Reactivity
Human
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4
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1
Host
Rat
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34
Clonality (Clone)
Monoclonal ()
Conjugate
This CD226 antibody is un-conjugated
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4
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1
1
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1
1
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1
Application
Flow Cytometry (FACS)
113
82
49
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21
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17
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7
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4
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3
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant human CD226/DNAM-1
Clone TX25
Isotype IgG2a
Specificity This antibody reacts with human CD226/DNAM-1 antigen.
Purification Protein G agarose
Alternative Name CD226 / DNAM1 (CD226 Antibody Abstract)
Background CD226/DNAM-1 (DNAX accessory molecule-1) is a 65 kDa type I transmembrane glycoprotein expressed on the majority of T cells, NK cells, monocytes, and a subset of B-cells. A soluble form (50 kDa) of CD226 is present in normal serum and the supernatant of cultured activated T cells. Ligand binding to CD226 results in phosphorylation of Ser329 and Tyr322, suggesting a role in signal transduction. CD226 acts as an adhesion molecule involved in the binding of certain tumor cells to CTL and NK cells and mediates their cytotoxicity. CD226 also stimulates TNF-α and IFN-γ secretion by alloantigen-specific T cells.Synonyms: DNAM-1, DNAX accessory molecule 1
Gene ID 10666
NCBI Accession NP_006557
UniProt Q15762
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-CD226 Molecule (CD226) antibody (ABIN1449202) anti-CD226 Molecule (CD226) antibody
Background publications Shibuya, Shirakawa, Kameyama, Honda, Tahara-Hanaoka, Miyamoto, Onodera, Sumida, Nakauchi, Miyoshi, Shibuya: "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation." in: The Journal of experimental medicine, Vol. 198, Issue 12, pp. 1829-39, 2003 (PubMed).