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MORC3 antibody

MORC3 Reactivity: Human, Mouse, Rat WB, IF Host: Mouse Monoclonal 17A9 unconjugated
Catalog No. ABIN1449250
  • Target See all MORC3 Antibodies
    MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))
    Reactivity
    • 11
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 8
    • 3
    Mouse
    Clonality
    • 10
    • 1
    Monoclonal
    Conjugate
    • 11
    This MORC3 antibody is un-conjugated
    Application
    • 10
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Specificity
    This antibody detects MORC3.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat
    Purification
    Protein A agarose
    Immunogen
    Recombinant human MORC3
    Clone
    17A9
    Isotype
    IgG1
    Top Product
    Discover our top product MORC3 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Upon receipt, store (in aliqouts) at -20 °C.
  • Target
    MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))
    Alternative Name
    MORC3 (MORC3 Products)
    Synonyms
    NXP2 antibody, ZCW5 antibody, ZCWCC3 antibody, 1110051N18Rik antibody, AI452146 antibody, BF318192 antibody, D16Jhu32e antibody, Zcwcc3 antibody, sb:cb561 antibody, sb:cb69 antibody, zgc:101052 antibody, fb73c08 antibody, wu:fb73c08 antibody, zgc:162471 antibody, morc3 antibody, MORC family CW-type zinc finger 3 antibody, microrchidia 3 antibody, MORC family CW-type zinc finger 3b antibody, MORC family CW-type zinc finger 3a antibody, MORC family CW-type zinc finger 3 S homeolog antibody, MORC3 antibody, Morc3 antibody, morc3b antibody, morc3a antibody, morc3.S antibody
    Background
    MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
    Gene ID
    23515
    NCBI Accession
    NP_056173
    UniProt
    Q14149
    Pathways
    Maintenance of Protein Location
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