Integrin beta 3 antibody (ITGB3)

Details for Product anti-ITGB3 Antibody No. ABIN1449278, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Alternatives
anti-Mouse (Murine) Integrin beta 3 antibody for Blocking Reagent
Reactivity
Mouse (Murine)
585
239
203
28
27
25
24
19
16
13
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
Host
Rat
369
231
52
29
18
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is un-conjugated
78
53
26
20
16
13
12
11
11
10
9
7
7
7
7
6
6
6
6
6
6
5
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
418
273
163
136
112
91
79
75
64
27
13
13
8
6
6
5
5
4
2
2
2
2
1
1
1
Options
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Immunogen Mouse platelet
Clone 1-55-4
Isotype IgG2a
Cross-Reactivity (Details) Species reactivity (tested):Mouse. Not Human (PBCM cells on Flow cytometry).
Purification Protein G agarose
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (aIIbß3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 10090
UniProt O54890
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Integrin beta 3 antibody (ITGB3) (ABIN1449278) anti-Integrin beta 3 (ITGB3) antibody
Western Blotting (WB) image for anti-Integrin beta 3 antibody (ITGB3) (ABIN1449278) anti-Integrin beta 3 (ITGB3) antibody (Image 2)
Background publications Jonker, Schinkel: "Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3)." in: The Journal of pharmacology and experimental therapeutics, Vol. 308, Issue 1, pp. 2-9, 2004 (PubMed).

De Nichilo, Shafren, Carter, Berndt, Burns, Boyd: "A common epitope on platelet integrin alpha IIb beta 3 (glycoprotein IIbIIIa, CD41b/CD61) and alpha M beta 2 (Mac-1, CDIIb/CD18) detected by a monoclonal antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 284-8, 1996 (PubMed).