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Integrin beta 3 antibody

ITGB3 Reactivity: Mouse WB, FACS, IP Host: Rat Monoclonal 1-55-4 unconjugated
Catalog No. ABIN1449278
  • Target See all Integrin beta 3 (ITGB3) Antibodies
    Integrin beta 3 (ITGB3)
    Reactivity
    • 176
    • 86
    • 50
    • 16
    • 15
    • 13
    • 12
    • 10
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 118
    • 61
    • 8
    • 1
    Rat
    Clonality
    • 112
    • 74
    Monoclonal
    Conjugate
    • 96
    • 16
    • 12
    • 11
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Integrin beta 3 antibody is un-conjugated
    Application
    • 125
    • 78
    • 51
    • 49
    • 27
    • 24
    • 23
    • 20
    • 15
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse. Not Human (PBCM cells on Flow cytometry).
    Purification
    Protein G agarose
    Immunogen
    Mouse platelet
    Clone
    1-55-4
    Isotype
    IgG2a
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Upon receipt, store (in aliqouts) at -20 °C.
  • Target
    Integrin beta 3 (ITGB3)
    Alternative Name
    CD61 / ITGB3 (ITGB3 Products)
    Synonyms
    BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody
    Background
    Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (aIIbß3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
    Gene ID
    10090
    UniProt
    O54890
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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