ATM antibody (Ataxia Telangiectasia Mutated)

Details for Product anti-ATM Antibody No. ABIN1449283, Supplier: Log in to see
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated homolog (human)
  • tefu
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • AaeL_AAEL014900
  • MGYG_07634
  • PGTG_14279
  • Atm
  • LOC100349299
Alternatives
anti-Human ATM antibody for Biochemical Assay
Reactivity
Human
352
157
77
27
8
1
1
1
1
Host
Mouse
229
96
17
9
3
Clonality (Clone)
Monoclonal ()
Conjugate
This ATM antibody is un-conjugated
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11
10
9
6
6
5
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
213
125
109
88
86
71
59
45
27
21
13
6
4
4
2
2
2
1
1
Options
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Immunogen Carrier protein (CP) conjugated synthetic peptide
Sequence CP-CFIKKPFDRG EVESMEDDTN GN
Clone 4H1
Isotype IgG1
Specificity This antibody reacts with ATM.
Cross-Reactivity (Details) Species reactivity (tested):Human
Alternative Name ATM (ATM Antibody Abstract)
Background ATM (ataxia telangiectasia mutated) encodes a 350-370 kDa protein. The ATM protein belongs to a family of protein kinases that appear to be involved in cell cycle control and DNA damage response. ATM kinase activity is enhanced immediately after exposure of cells to DNA double strand breaks. The C-terminal region of the protein has extensive homology to the catalytic domain of PI-3 (phosphatydilinositol-3) kinase, FAT (FRAP/ATM/TRAPP), and FAT-C (FAT-carboxy-terminal). ATM activates p53, increasing p21Cip1 levels, thus blocking activation of cdk2. That results in blockage of the G1/S transition.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
Gene ID 472
NCBI Accession NP_000042
UniProt Q13315
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Protein A agarose, PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (ABIN1449283) anti-Ataxia Telangiectasia Mutated (ATM) antibody
Background publications Canman, Lim, Cimprich, Taya, Tamai, Sakaguchi, Appella, Kastan, Siliciano: "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53." in: Science (New York, N.Y.), Vol. 281, Issue 5383, pp. 1677-9, 1998 (PubMed).

Banin, Moyal, Shieh, Taya, Anderson, Chessa, Smorodinsky, Prives, Reiss, Shiloh, Ziv: "Enhanced phosphorylation of p53 by ATM in response to DNA damage." in: Science (New York, N.Y.), Vol. 281, Issue 5383, pp. 1674-7, 1998 (PubMed).

Savitsky, Sfez, Tagle, Ziv, Sartiel, Collins, Shiloh, Rotman: "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species." in: Human molecular genetics, Vol. 4, Issue 11, pp. 2025-32, 1996 (PubMed).