Ubiquitin antibody

Details for Product No. ABIN1449301, Supplier: Log in to see
Antigen
  • CG11624
  • DmUb
  • DmUbi-p63E
  • Dmel\\CG11624
  • Ub
  • Ubi-P63e
  • Ubi-p
  • Ubi63E
  • Ubi63p
  • Ubip
  • Ubiq
  • Ubp
  • ubi
  • ubi-p63E
  • ubi63E
  • CG18282
  • CG32744
  • CR32744
  • DmUbi-p5E
  • Dmel\\CG32744
  • ubiquitin
  • si:dz180g5.5
  • si:busm1-180g5.5
  • LOC100194618
  • UBIQ
  • Ubiquitin
  • LOC100282068
  • polyubiquitin-B-like
  • Ubiquitin-63E
  • Ubiquitin-5E
  • transmembrane and ubiquitin-like domain containing 2
  • polyubiquitin
  • polyubiquitin containing 7 ubiquitin monomers
  • Ubiquitin
  • ubiquitin
  • ubiquitin B
  • LOC100716362
  • Ubi-p63E
  • Ubi-p5E
  • tmub2
  • LOC100194618
  • LOC100282068
  • LOC100190766
  • LOC100135798
  • UBB
Reactivity
Cow (Bovine), Human
324
200
189
184
59
47
38
36
31
28
27
27
27
26
26
25
24
13
8
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Host
Mouse
226
210
5
4
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
18
15
13
13
13
12
8
8
8
8
8
8
8
8
8
8
6
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
372
242
187
135
124
120
68
33
23
13
13
12
7
3
1
1
1
Options
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Immunogen Bovine erythrocyte ubiquitin
Clone 1B3
Isotype IgG1
Specificity This antibody reacts with erythrocyte ubiquitin. It does not react with multi ubiquitin.
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine
Purification Protein A agarose
Background Ubiquitin is a polypeptide of 76 amino acid residues, and widely distributed protein in eukaryotic cells. This protein is also highly conserved among eukaryotic cells. There are several reports showed that intracellular abnormal and short-lived proteins are degraded through an ubiquitin dependent proteolytic pathway. In the ubiquitin dependent pathway, a target protein is tagged with multi-ubiquitin molecules.Synonyms: Polyubiquitin-B, UBB
Gene ID 7314
UniProt P0CG47
Research Area Neurology, Proteolysis / Ubiquitin, Alzheimer's Disease, Proteases, Amino Acids
Pathways Mitotic G1-G1/S Phases
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin antibody (ABIN1449301) anti-Ubiquitin antibody
Background publications Tanji, Tanaka, Mori, Kito, Takahashi, Wakabayashi, Kamitani: "NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1." in: The American journal of pathology, Vol. 169, Issue 2, pp. 553-65, 2006 (PubMed).

Komatsu, Waguri, Ueno, Iwata, Murata, Tanida, Ezaki, Mizushima, Ohsumi, Uchiyama, Kominami, Tanaka, Chiba: "Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice." in: The Journal of cell biology, Vol. 169, Issue 3, pp. 425-34, 2005 (PubMed).

Akiyoshi, Hatakeyama, Pitkänen, Mouri, Doucas, Kudoh, Tsurugaya, Uchida, Matsushima, Oshikawa, Nakayama, Shimizu, Peterson, Matsumoto: "Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33984-91, 2004 (PubMed).

Okumura, Hatakeyama, Matsumoto, Kamura, Nakayama: "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis." in: The Journal of biological chemistry, Vol. 279, Issue 51, pp. 53533-43, 2004 (PubMed).

Miyazaki, Fujita, Ozaki, Kato, Kurose, Sakamoto, Kato, Goto, Itoyama, Aoki, Nakagawara: "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11327-35, 2004 (PubMed).

Hatakeyama, Matsumoto, Yada, Nakayama: "Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 6, pp. 533-48, 2004 (PubMed).

Zhang, Tomida, Koshimizu, Ogiso, Lei, Tsuruo: "Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex." in: Cancer research, Vol. 64, Issue 3, pp. 1114-21, 2004 (PubMed).

Uchida, Hatakeyama, Matsushima, Han, Ishido, Hotta, Kudoh, Shimizu, Doucas, Nakayama, Kuroda, Matsumoto: "AIRE functions as an E3 ubiquitin ligase." in: The Journal of experimental medicine, Vol. 199, Issue 2, pp. 167-72, 2004 (PubMed).